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Human/Mouse SMOC-2 Antibody

Catalog #: AF5140
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF5140
AF5140-SP
Product Details
Citations (2)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse SMOC-2 Antibody Summary

Species Reactivity
Human, Mouse
Specificity
Detects human and mouse SMOC‑2 in direct ELISAs and Western Blots
Source
Polyclonal Sheep IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human SMOC-2 
Gln22-Gly446
Accession # Q9H3U7
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human SMOC‑2 (Catalog # 5140-SM)
Recombinant Mouse SMOC‑2 (Catalog # 6075-SM)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SMOC-2

SMOC-2 (secreted modular calcium-binding protein 2; also SMAP2) is a 55 kDa glycoprotein member of the SPARC family of matricellular proteins. It is widely expressed, perhaps by endothelium and apparently participates in both growth factor signaling and ECM organization. Mature human SMOC-2 is 425 amino acids (aa) in length. It contains one Kazal-like domain (aa 40‑84), two thyroglobulin type-1 segments (aa 87‑153 and 213‑281) and two EF-hand sequences (aa 347‑382 and 384‑419). There are three splice variants. One shows a 13 aa substitution for aa 442‑446, another shows an 11 aa insertion after Thr170 and a third represents a combination of the above two variations. Over aa 22‑446, human SMOC-2 shares 95% aa identity with mouse SMOC-2.

Long Name
Secreted Modular Calcium-binding Protein 2
Entrez Gene IDs
64094 (Human); 64074 (Mouse); 292401 (Rat)
Alternate Names
bA270C4A.1; bA37D8.1; dJ421D16.1; MST117; MSTP117; MSTP140; SMAP2; SMAP-2; SMAP2Secreted modular calcium-binding protein 2; SMOC2; SMOC-2; smooth muscle associated protein 2; Smooth muscle-associated protein 2; SPARC related modular calcium binding 2; SPARC-related modular calcium-binding protein 2; thyroglobulin type-1 repeat containing protein

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Citations for Human/Mouse SMOC-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Characterization of Matricellular Protein Expression Signatures in Mechanistically Diverse Mouse Models of Kidney Injury
    Authors: D Feng, C Ngov, N Henley, N Boufaied, C Gerarduzzi
    Sci Rep, 2019-11-13;9(1):16736.
    Species: Mouse
    Sample Types: Protein
    Applications: Western Blot
  2. Silencing SMOC2 ameliorates kidney fibrosis by inhibiting fibroblast to myofibroblast transformation
    Authors: C Gerarduzzi, RK Kumar, P Trivedi, AK Ajay, A Iyer, S Boswell, JN Hutchinson, SS Waikar, VS Vaidya
    JCI Insight, 2017-04-20;2(8):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Functional Assay

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