Human MSP alpha Chain Antibody Summary
Met1-Gly711
Accession # AAA59872
Applications
Human MSP Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: MSP/MST1
MSP, also known as hepatocyte growth factor-like protein (HGFl), and scatter factor-2 (SF2), is a member of the HGF family of growth factors. It is secreted as a single chain inactive precursor which is proteolytically activated to yield a biologically active disulfide-linked heterodimer of the alpha and beta chains. MSP induces keratinocyte proliferation, bone resorption, and cell migration and shape change in resident macrophages. Heterodimeric MSP binds to and activates the cell surface receptor tyrosine kinase, RON/STK, which is expressed on mature macrophages, keratinocytes, and vascular endothelium of wounded skin.
Product Datasheets
Citations for Human MSP alpha Chain Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root ganglia
Authors: Viventi S, Frausin S, Howden SE et al.
Stem cells translational medicine
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HIV?1 downregulates the expression and phosphorylation of receptor tyrosine kinase by targeting the NF??B pathway
Mol Med Rep, 2016-07-08;0(0):.
Species: Human
Sample Types: Whole Blood
Applications: ELISA Development (Capture) -
Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.
Authors: Kauder, Steven E, Santell, Lydia, Mai, Elaine, Wright, Lilyan Y, Luis, Elizabet, N'Diaye, Elsa N, Lutman, Jeff, Ratti, Navneet, Sa, Susan M, Maun, Henry R, Stefanich, Eric, Gonzalez, Lino C, Graham, Robert R, Diehl, Lauri, Faubion, William, Keir, Mary E, Young, Judy, Chaudhuri, Amitabha, Lazarus, Robert A, Egen, Jackson
PLoS ONE, 2013-12-23;8(12):e83958.
Species: Human
Sample Types: Serum
Applications: ELISA Development -
Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R
Authors: Kerrington R. Molhoek, Amber L. Shada, Mark Smolkin, Sudhir Chowbina, Jason Papin, David L. Brautigan et al.
Melanoma Research
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We used this antibody for developing a sandwich ELISA in combination with protein (352-MS) and pAb (AF352). This combination worked well and detected human MSP in serum samples efficiently.
