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Human MUC-19 Antibody

Catalog #: MAB8245 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB8245
MAB8245-SP
MUC‑19 in Human Salivary Gland.
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Human MUC-19 Antibody Summary

Species Reactivity
Human
Specificity
Detects human MUC-19 in direct ELISAs.
Source
Monoclonal Mouse IgG1 Clone # 876013
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human MUC-19
Lys5606-Gly5767
Accession # Q7Z5P9
Formulation
Supplied as a 0.2 μm filtered solution in PBS. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Immunohistochemistry
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry MUC-19 antibody in Human Salivary Gland by Immunohistochemistry (IHC-P). View Larger

MUC‑19 in Human Salivary Gland. MUC-19 was detected in immersion fixed paraffin-embedded sections of human salivary gland using Mouse Anti-Human MUC-19 Monoclonal Antibody (Catalog # MAB8245) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to mucosal cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C, as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after opening.
  • 6 months, -20 to -70 °C under sterile conditions after opening.

Background: MUC-19

MUC-19 is a 6,254 amino acid member of the Mucin family of gel-forming glycoproteins.  MUC-19 is expressed in corneal epithelial cells in the eye, conjuctival goblet and epithelial cells and lacrimal gland cells as well as by mucous cells of the submandibular gland and submucosal gland of the trachea.  MUC-19 expression is reduced in patients with Sjogren syndrome (1,2). In a middle ear model of inflammatory response, MUC-19 is up-regulated in epithelial cells by exposure to cytokines including TNF-alpha, IL-1 beta, IL-5 and IL-8 (3).

 

References
  1. Yu, D. et al. (2008) Exp Eye Res. 86 :403.
  2. Chen, Y. et al. (2004) Am J Respir Cell Mol Biol 30:155.
  3. Kerschner, J. et al. (2009) Glycoconj J. 26:1275.
Long Name
Mucin 19, Oligomeric
Entrez Gene IDs
283463 (Human)
Alternate Names
MUC19; MUC-19

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