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Human Neuroplastin (NP_059429) VersaClone cDNA

Catalog #: RDC2773 Datasheet / COA / SDS
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RDC2773
Human Neuroplastin (NP_059429) VersaClone cDNA
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Human Neuroplastin (NP_059429) VersaClone cDNA Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

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Background: Neuroplastin

Neuroplastin (NPTN; also stromal cell-derived receptor 1 and Np55) is a 52 - 57 kDa member of the Ig-superfamily. Neuroplastin is widely expressed and likely serves as a cell adhesion molecule in multiple tissues. Human Neuroplastin is 282 amino acids (aa) in length. It is a type I transmembrane glycoprotein that contains two Ig-like domains (aa 32 - 119 and 122 - 213) and a 38 aa cytoplasmic region (aa 245 - 282).

There is a brain-enriched 65 kDa form of Neuroplastin (Np65) that negatively regulates LTP in the hippocampus. Neuroplastin 65 contains an N-terminal 116 aa Ig-like domain-containing insert after Asn30 and interacts homotypically. Notably, human and rodent Np65 expression patterns are different in brain, with rodent Np65 not predominating in cerebellum. Over aa 29 - 336, human Np65 is 95% aa identical to mouse Np65.

Entrez Gene IDs
27020 (Human); 20320 (Mouse); 56064 (Rat)
Alternate Names
AW554172; GP55; GP55Stromal cell-derived receptor 1; GP65SDR-1; GP66; MGC102805; Neuroplastin; np55; np65; NPTN; SDFR1; SDFR1DKFZp686L2477; SDR1; SDR1stromal cell derived factor receptor 1

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