Human NrCAM Isoform 3 Antibody Summary
Leu30-Asn600 (Ala526Pro)
Accession # Q14CA1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: NrCAM
NgCAM related cell adhesion molecule (NrCAM), also known as Bravo, belongs to the L1 family of cell adhesion molecules, which also include L1, neurofascin and close homolog of L1 (CHL-1) (1). These molecules are type I transmembrane proteins that have 6 Ig-like domains and 4‑5 fibronectin type III-like domains in their extracellular domain. They also shared a conserved cytoplasmic region containing an ankyrin-binding site. L1 family cell adhesion molecules are expressed primarily in the nervous system where they share overlapping functions in controlling axonal growth and guidance (1, 2). NrCam mediates homophilic adhesion as well as heterophilic adhesion with a number of neuronal adhesion molecules including contactin, TAG-1/contactin-2, neurofascin and receptor tyrosine phosphatase beta (RPTP beta ) (3‑5). NrCAM has been implicated in the axogenesis of multiple neuronal populations including sensory axons and commissural axons in the spinal cord of chick embryos. It also plays a role in cerebellar granule cell development, and is required in node of Ranvier formation (5, 6).
- Hortsch, M. (2000) Mol. Cell. Neurosci. 15:1.
- Stoeckli, E.T. and L.T. Landmesser (1995) Neruon 14:1165.
- Mauro, V.P. et al. (1992) 119:191.
- Fustig, M. Sakurai, T. and M. Grumet (1999) Dev. Bio. 209:340.
- Sakurai, T. et al. (2001) J. Cell Bio. 154:1259.
- Custer, A.W. et al. (2003) J. Neuroscience 23:10032.
Product Datasheets
Citations for Human NrCAM Isoform 3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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High Nr-CAM expression is associated with favorable phenotype and late PSA recurrence in prostate cancer treated by prostatectomy.
Authors: Tsourlakis, M C, Walter, E, Quaas, A, Graefen, M, Huland, H, Simon, R, Sauter, G, Steurer, S, Schlomm, T, Minner, S
Prostate Cancer Prostatic Dis, 2013-01-22;16(2):159-64.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
CHL1 and NrCAM are primarily expressed in low grade pediatric neuroblastoma
Authors: Robin Wachowiak, Steffi Mayer, Anne Suttkus, Illya Martynov, Martin Lacher, Nathaniel Melling et al.
Open Med (Wars)
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