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Human NRG1 Isoform GGF2 Antibody

Catalog #: AF2015
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF2015
AF2015-SP
Product Details
Citations (3)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human NRG1 Isoform GGF2 Antibody Summary

Species Reactivity
Human
Specificity
Detects human NRG1 Isoform GGF2 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross‑reactivity with recombinant human (rh) NRG‑1 alpha EGF domain, rhNRG1-beta 1 extracellular domain, rhNRG1-beta 1 EGF domain, rhSMDF, and recombinant mouse NRG3 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human NRG1 Isoform GGF2
Gly51-Cys248
Accession # NP_039256
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human NRG1 Isoform GGF2

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Neuregulin-1 Isoform GGF2

By alternative splicing, the Neuregulin 1 gene ecodes at least 10 secreted or membrane-bound proteins, all of which contain an EGF-like domain. Neuregulin 1 isoforms bind and signal via the ErbB family of receptor tyrosine kinases. Isoform GGF2 contains a unique kringle-like domain, plus Ig and EGF-like domains that are also present in multiple Neuregulin 1 isoforms.

Entrez Gene IDs
3084 (Human); 211323 (Mouse); 112400 (Rat)
Alternate Names
GGF2; ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; Neuregulin1 Isoform GGF2; Neuregulin-1 Isoform GGF2; NRG1-IT2; SMDF

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Citations for Human NRG1 Isoform GGF2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction
    Authors: Tom J Parry
    Eur. J. Pharmacol, 2016-12-16;796(0):76-89.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Development (Capture)
  2. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells
    Authors: Kristian W. Pajtler, Ellen Mahlow, Andrea Odersky, Sven Lindner, Harald Stephan, Ivo Bendix et al.
    Oncotarget
  3. Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli
    Authors: S.B. Taylor, A.R. Taylor, J.A. Markham, A.M. Geurts, B.Z. Kanaskie, J.I. Koenig
    Physiology & Behavior

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