Human Pax5/BSAP PE-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Pax5/BSAP

Pax5, also known as BSAP (B-cell-specific transcription factor) is a 44-48 kDa monomeric protein that belongs to the paired box transcription factor family of molecules. Human Pax5 is 391 amino acids (aa) in length and contains the paired DNA-binding domain over aa 16-142. More than 10 alternatively spliced isoforms with MW ranging from 25-40 kDa have been reported that likely possess different transactivation properties. Splicing may involve all but the first N-terminal 70 aa. Pax5 is principally found in pro-B cells and mature B cells where it promotes a B cell phenotype at the expense of plasma cell formation. In conjunction with Bcl-6, Pax5 represses XBP-1 and Blimp-1 expression. Over aa 141-391, human Pax5 shares 99% aa sequences identity with mouse Pax5.

Product Datasheets

Related Research Areas

• Acute Lymphoblastic Leukemia
• B Cell Development and Differentiation
• B Cell Markers
• Paired Box Transcription Factors
• Transcription Factors in the Akt Pathway