Human PLUNC Antibody

Name: Human PLUNC Antibody
Brand: R&D Systems
SKU: MAB1897
Rating: 5 (1 reviews)

Catalog #: MAB1897
7 Citations 1 Review Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB1897
MAB1897-SP

All PLUNC Antibodies

Product Details

Citations (7)

FAQs

Supplemental Products

Reviews (1)

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human PLUNC Antibody Summary

Species Reactivity

Human

Specificity

Detects human PLUNC in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG_2B Clone # 251512

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

E. coli-derived recombinant human PLUNC
Gln20-Val256
Accession # Q9NP55

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human PLUNC

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PLUNC

PLUNC, also named SPLUNC1, is a secreted protein that is expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. It is structurally related to bactericidal/permeability-increasing protein (BPI) and lipopolysaccaride binding protein (LBP), which are central to the host defense against gram-negative bacteria. PLUNC belongs to the short subfamily of PLUNC family proteins and has homology only to the N-terminal domains of BPI. PLUNC may function in the innate immune response against bacteria.

Long Name

Palate, Lung, and Nasal Epithelium Associated

Entrez Gene IDs

51297 (Human)

Alternate Names

bA49G10.5; BPIFA1; ligand-binding protein RYA3; LPLUNC3; Lung-specific protein X; LUNX; LUNXNASG; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; palate, lung and nasal epithelium associated; palate, lung and nasal epithelium carcinoma associated; PLUNC; protein Plunc; Secretory protein in upper respiratory tracts; SPLUNC1; SPLUNC1SPURT; tracheal epithelium enriched protein; Tracheal epithelium-enriched protein; Von Ebner protein Hl

Product Datasheets

Product Datasheet

COA

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Related Research Areas

Citations for Human PLUNC Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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Increased susceptibility to otitis media in a Splunc1-deficient mouse model
Authors: Jennifer A. Bartlett, David K. Meyerholz, Christine L. Wohlford-Lenane, Paul W. Naumann, Nita H. Salzman, Paul B. McCray
Disease Models & Mechanisms
SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection.
Authors: Liu Y, Bartlett J, Di M, Bomberger J, Chan Y, Gakhar L, Mallampalli R, McCray P, Di Y
Am J Pathol, 2013-03-15;182(5):1519-31.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Western Blot
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung.
Authors: Pezzulo AA, Tang XX, Hoegger MJ, Alaiwa MH, Ramachandran S, Moninger TO, Karp PH, Wohlford-Lenane CL, Haagsman HP, van Eijk M, Banfi B, Horswill AR, Stoltz DA, McCray PB, Welsh MJ, Zabner J
Nature, 2012-07-04;487(7405):109-13.
Species: Porcine
Sample Types: Tissue Secretion
Applications: Western Blot
The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway.
Authors: McGillivary G, Bakaletz LO
PLoS ONE, 2010-10-07;5(10):e13224.
Species: Chinchilla
Sample Types: Nasal Lavage Fluid
Applications: Western Blot
Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers.
Authors: Steiling K, Kadar AY, Bergerat A
PLoS ONE, 2009-04-09;4(4):e5043.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay
Authors: Karl G. Kohlgraf, Abbey R. Ackermann, Kindra K. Burnell, Rupasree N. Srikantha, Sophie A. Joly, Jennifer A. Bartlett et al.
Archives of Oral Biology
Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells
Authors: Yung-An Tsou, Chia-Der Lin, Hui-Chen Chen, Hui-Ying Hsu, Lii-Tzu Wu, Chuan Chiang-Ni et al.
PLOS ONE