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Human Pro-BMP‑2 Antibody

Catalog #: MAB2260
4 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB2260
MAB2260-SP
Product Details
Citations (4)
FAQs
Supplemental Products
Reviews (1)
Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Pro-BMP‑2 Antibody Summary

Species Reactivity
Human
Specificity
Detects the pro region of the human BMP-2 precursor in direct ELISAs and Western blots. This antibody does not recognize mature recombinant human BMP‑2.
Source
Monoclonal Mouse IgG2A Clone # 253717
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human BMP‑2
Ala22-Lys281 (Arg245Ser, Arg279Ser)
Accession # P12643
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human BMP‑2 (Pro Region)
Immunohistochemistry
8-25 µg/mL
Immersion fixed paraffin-embedded sections of human pancreatic cancer tissue

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: BMP-2

BMP-2, a member of the transforming growth factor beta (TGF-beta ) superfamily, is synthesized as an inactive precursor protein. The N-terminal pro region is removed via proteolytic cleavage to liberate a free 114 amino acid C-terminal fragment that forms a disulfide-linked active BMP-2 homodimer. BMP-2 modulates growth and differentiation of many cell types through its interaction with heterodimeric receptors composed of BMPR-II complexed with BMPR-IA or -IB.

Long Name
Bone Morphogenetic Protein 2
Entrez Gene IDs
650 (Human); 12156 (Mouse); 29373 (Rat)
Alternate Names
BDA2; BMP2; BMP-2; BMP-2A; BMP2ABone morphogenetic protein 2A; bone morphogenetic protein 2; SSFSC

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Citations for Human Pro-BMP‑2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Expression of bone morphogenetic protein 2, 4, 5, and 7 correlates with histological activity of otosclerotic foci
    Authors: Péter Csomor, Balázs Liktor, Bálint Liktor, Zoltán Szekanecz, István Sziklai, Tamás Karosi
    Acta Oto-Laryngologica
  2. Expression of BMP-2 in Vascular Endothelial Cells of Recipient May Predict Delayed Graft Function After Renal Transplantation
    Authors: Bojan Jelakovic
    Kidney Blood Press. Res., 2016-11-11;41(6):781-793.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  3. Targeting of bone morphogenetic protein growth factor complexes to fibrillin.
    Authors: Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY
    J. Biol. Chem., 2008-03-13;283(20):13874-88.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Western Blot
  4. Platelet-rich plasma decreases fibroblastic activity and woven bone formation with no significant immunohistochemical effect on long-bone healing: An experimental animal study with radiological outcomes
    Authors: İbrahim Deniz Canbeyli, Rahmi Can Akgun, Orcun Sahin, Aysen Terzi, İsmail Cengiz Tuncay
    J Orthop Surg (Hong Kong)

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Human Pro-BMP‑2 Antibody
By Anonymous on 06/17/2022
Application: IHC Sample Tested: Pancreatic cancer tissue Species: Human
Immunohistochemistry Human Pro-BMP‑2 Antibody MAB2260