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Human PTPN13/PTPL1 Antibody

Catalog #: MAB3577
1 Citation Datasheet / COA / SDS
Newer Version Available: AF3577
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Discontinued Product

MAB3577 has been discontinued and is replaced by AF3577.

Detection of Human PTPN13/PTPL1 by Western Blot.
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Citations (1)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human PTPN13/PTPL1 Antibody Summary

Species Reactivity
Human
Specificity
Detects endogenous human PTPN13/PTPL1 in Western blots.
Source
Monoclonal Mouse IgG2B Clone # 359313
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human PTPN13/PTPL1
His2-Arg500
Accession # Q12923
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human PTPN13/PTPL1 antibody by Western Blot. View Larger

Detection of Human PTPN13/PTPL1 by Western Blot. Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Human PTPN13/PTPL1 Monoclonal Antibody (Catalog # MAB3577) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PTPN13/PTPL1 at approximately 260 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 4.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PTPN13/PTPL1

Protein Tyrosine Phosphatase, Non-receptor Type 13, also called PTPN13, PTPL1, FAP-1, hPTP1E, and PTP-BAS, is a 260 kDa intracellular protein that removes phosphates from tyrosine residues. Genetic aberrations in PTPN13 have been reported in a wide variety of cancers, including bone, colon, hepatocellular, and germ cell line. Elevated levels of PTPN13 in cancer cell lines have also been correlated with resistance to Fas-induced apoptosis, possibly due to prevention of CD95 reaching the cell surface.

Long Name
Protein Tyrosine Phosphatase, Non-receptor Type 13
Entrez Gene IDs
5783 (Human); 19249 (Mouse); 498331 (Rat)
Alternate Names
EAP-1; FAP-1; hPTPE1; PNP1; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associatedphosphatase); protein-tyrosine phosphatase 1, Fas-associated; PTP1E; PTP1EDKFZp686J1497; PTP-BAS; PTP-BASEC 3.1.3.48; PTP-BL; PTP-E1; PTPL1; PTPL1nonreceptor type 13; PTPLE; PTPN13; tyrosine-protein phosphatase non-receptor type 13

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Citation for Human PTPN13/PTPL1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Ligation of erythrocyte CR1 induces its clustering in complex with scaffolding protein FAP-1.
    Authors: Ghiran I, Glodek AM, Weaver G, Klickstein LB, Nicholson-Weller A
    Blood, 2008-08-06;112(8):3465-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Western Blot

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