Human RAGE (NP_001127) VersaClone cDNA

Human RAGE (NP_001127) VersaClone cDNA Summary

Specifications

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Background: RAGE/AGER

RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.

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Related Research Areas

• Adhesion Molecules in Angiogenesis
• Blood-brain Barrier Transporters
• Cell Structure and Signaling Molecules
• Cytokine and Growth Factor Receptors on VSMC
• Diabetes
• Diabetic Peripheral Neuropathy
• Glucose Homeostasis
• Immune Regulatory Molecules on Endothelial Cells
• Inflammatory Mediators
• Integrins and Associated Molecules
• Microglia Activation
• Neurodegenerative Disease
• Platelet Immune Receptors
• ROS and Stress Resistance
• Uptake of Amyloid beta by Glia Cells