Human RIPK1/RIP1 (NP_003795.2) VersaClone cDNA

Human RIPK1/RIP1 (NP_003795.2) VersaClone cDNA Summary

Specifications

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Background: RIPK1/RIP1

RIPK1 (Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1), also known as RIP1, contains an N-terminal protein kinase domain, a C-terminal death domain, and a unique internal region called the intermediate domain. It is a serine/threonine protein kinase and is constitutively expressed in many tissues. RIPK1 interacts with the cytoplasmic death domain of FAS and TNF receptors, and is an important element in apoptotic processes. RIPK1 has been shown to interact with a number of proteins including TRADD, TRAF1, TRAF2, and TRAF3, to form larger signaling complexes. These complexes, in turn, activate specific signaling cascades, such as NFkB.

Related Research Areas

• Apoptosis Adaptor Proteins
• Immunoglobulin-Like Domain Transcription Factors
• Intracellular Kinases
• Intracellular Kinases in the Akt Pathway
• NFkB Pathway
• NOD-like Receptors and the Inflammasome
• RIG-I-like Receptors
• TNF Superfamily
• TNF Superfamily Regulators
• Toll-Like Receptors