Human Serpin B6 Biotinylated Antibody

Catalog #: BAF4336 Datasheet / COA / SDS

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BAF4336

All Serpin B6 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Serpin B6 Biotinylated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Serpin B6 in Western blots. In Western blots, approximately 5% cross-reactivity with recombinant human (rh) Serpin B8 and rhSerpin B9 is observed.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Serpin B6
Asp2-Pro376
Accession # P35237

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Label

Biotin

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human Serpin B6

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Serpin B6

Serpin B6 (serine protease inhibitor-clade B#6; also placental thrombin inhibitor) is a 42 kDa, cytosolic member of the ovalbumin (clade B)-subfamily, Serpin superfamily of protease inhibitors. It is produced by multiple cell types (keratinocytes; monocytes; mast cells), and shows inhibitory activity towards thrombin, plasmin and chymotrypsin. Human Serpin B6 is 376 amino acids (aa) in length. An active inhibitor site lies between Glu327 and Met338. Multiple potential isoforms exist. One shows a 28 aa substitution for the N-terminal 191 amino acids. Three others have alternate start sites that vary from 14‑33 aa’s upstream of the standard start site. Human Serpin B6 shares 76% aa identity with mouse Serpin B6.

Entrez Gene IDs

5269 (Human); 20719 (Mouse); 291085 (Rat)

Alternate Names

CAP; CAPMGC111370; Cytoplasmic antiproteinase; deafness, autosomal recessive 91; DFNB91; Peptidase inhibitor 6; PI6; PI-6; PI6MSTP057; Placental thrombin inhibitor; protease inhibitor 6 (placental thrombin inhibitor); PTI; PTIDKFZp686I04222; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; Serpin B6; serpin peptidase inhibitor, clade B (ovalbumin), member 6; SPI3