Human Serpin C1/Antithrombin-III Biotinylated Antibody Summary
His33-Lys464
Accession # P01008
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Serpin C1/Antithrombin-III
Serpin C1 is a member of the Serpin superfamily of the serine protease inhibitors (1). It is the principal plasma Serpin of blood clotting proteases and inhibits thrombin as well as several factors such as Xa (2). Similar to Serpins A5 and D1, its thrombin inhibitory activity is enhanced by heparin. Hereditary and acquired Serpin C1 deficiency is the cause of an increased thrombotic tendency in many cases (3). For example, acquired Serpin C1 deficiency is a common condition in sepsis, after major trauma or surgery (4).
- Silverman, G.A. et al. (2001) J. Biol. Chem. 276:33293.
- Chuang, Y.-J. et al. (2001) Biochemistry 40:6670.
- Vinazzer, H. (1999) Semin. Thromb. Hemost. 25:257.
- Risberg, B. (1998) Blood Coagul. Fibrinolysis Suppl. 3:S3.
Product Datasheets
Citations for Human Serpin C1/Antithrombin-III Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis
Authors: Kraaijvanger, R;Janssen Bonás, M;Grutters, JC;Paspali, I;Veltkamp, M;de Kleijn, DPV;van Moorsel, CHM;
Respiratory research
Species: Human
Sample Types: Serum
Applications: ELISA Detection -
Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction
Authors: XC Lim, C Huang, SMJM Yatim, SY Chong, SH Tan, X Yang, CL Heldt, J Pedersen, M Talanker, H Modh, MG Wacker, G Pastorin, SP Chan, AM Richards, CJ Charles, MY Chan, JW Wang
International Journal of Molecular Sciences, 2022-12-25;24(1):.
Species: Human
Sample Types: Extracellular Vesicles
Applications: ELISA Detection -
Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles
Authors: JW Wang, YN Zhang, SK Sze, SM van de Weg, F Vernooij, AH Schoneveld, SH Tan, HH Versteeg, L Timmers, CSP Lam, DPV de Kleijn
Int J Mol Sci, 2017-12-29;19(1):.
Applications: Bioassay -
Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation.
Authors: Meyer-Siegler KL, Cox J, Leng L, Bucala R, Vera PL
Cancer Lett., 2009-09-16;290(1):49-57.
Species: Human
Sample Types: Plasma
Applications: ELISA Development
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