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Human SLURP1 Antibody

Catalog #: MAB4479
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB4479
MAB4479-SP
Product Details
Citations (1)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human SLURP1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human SLURP1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse SLURP1 is observed.
Source
Monoclonal Mouse IgG2A Clone # 569317
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human SLURP1
Ala22-Leu103
Accession # P55000
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
8-25 µg/mL
Immersion fixed paraffin-embedded sections of human lung and human placenta

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Sterile PBS to a final concentration of 0.5 mg/mL.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SLURP1

SLURP1 (Secreted Ly6/uPAR-related protein 1; also ARS Component B and ANUP) is a 9-10 kDa secreted member of the Ly6/uPAR Superfamily of proteins. It is expressed by restricted cell types, including sensory neurons, ciliated bronchial epithelium, T and B cells, and stratified squamous epithelium of the skin, vagina and esophagus. SLURP1 binds to the alpha 7 nicotinic acetylcholine receptor, which suggests it regulates Ca and Na transport. This translates into reduced TNF alpha release by macrophages, and activation of select cellular caspases. Mature human SLURP1 is 82 amino acids (aa) in length (aa 22-103). It contains one UPAR/Ly6 domain (aa 24‑73), and forms noncovalent homodimers. Mature human SLURP1 shares 67% aa identity with mouse SLURP1.

Long Name
Secreted Ly-6/uPAR-related Protein 1
Entrez Gene IDs
57152 (Human); 57277 (Mouse); 300016 (Rat)
Alternate Names
ANUPARS(component B)-81/S; ARS Component B; ArsB; ARSlymphocyte antigen 6-like secreted; LY6LS; MDMsecreted Ly-6/uPAR-related protein 1; neoplastic urinary protein; secreted LY6/PLAUR domain containing 1; secreted Ly6/uPAR related protein 1; SLURP1; SLURP-1

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Citation for Human SLURP1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Expression microarray analysis identifies novel epithelial-derived protein markers in eosinophilic esophagitis.
    Authors: Matoso, Andres, Mukkada, Vincent, Lu, Shaolei, Monahan, Renee, Cleveland, Kelly, Noble, Lelia, Mangray, Shamlal, Resnick, Murray B
    Mod Pathol, 2013-03-15;26(5):665-76.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC

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