Human SLX4 Antibody

Catalog #: MAB11246 Datasheet / COA / SDS

Recombinant Monoclonal Antibody

Catalog #	Availability	Size / Price	Qty
MAB11246-100
MAB11246-SP

Detection of SLX4 in RAW264.7 (Mouse) and A431 (Human) cells.

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Human SLX4 Antibody Summary

Specificity

Detects Human SLX4 immunogen sequences in Direct ELISA.

Source

Recombinant Monoclonal Rabbit IgG Clone # 2392A

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Synthetic peptide within amino acids 400-500 of the Human SLX4 protein sequence

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Immunocytochemistry

3-25 µg/mL

Immersion fixed RAW 264.7 Mouse Monocyte/Macrophage Cell line (Mouse) and A431 Human Epithelial Carcinoma Cell Line (Human) Cells

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunocytochemistry

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Detection of SLX4 in RAW264.7 (Mouse) and A431 (Human) cells. SLX4 was detected in immersion fixed RAW 264.7 Mouse Monocyte/Macrophage Cell line (Mouse) and A431 Human Epithelial Carcinoma Cell Line (Human) Cells using Rabbit Anti-Human SLX4 Monoclonal Antibody (Catalog # MAB11246) at 3 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (red; Catalog # NL004) and counterstained with DAPI (blue). Specific staining was localized to cell nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background:

SLX4 (also known as BTBD12 and FANCP) is a multidomain scaffold protein involved in DNA repair, where it has important roles in the final steps of homologous recombination. SLX4 hat interacts with three distinct nucleases: SLX1, ERCC4/XPF-ERCC1 and MUS81-EME1. Mutations in the gene are associated with the disease Fanconi anemia, a rare recessive disorder characterized by genome instability, congenital malformations, progressive bone marrow failure and predisposition to hematologic malignancies and solid tumors.

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Product Datasheet

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