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Human Somatostatin R2/SSTR2 APC-conjugated Antibody

Catalog #: FAB4224A
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB4224A
Detection of Somatostatin R2/SSTR2 in HEK293 Human Cell Line Transfected with Human Somatostatin R2/SSTR2 and eGFP by Flow Cytometry.
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Citations (3)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Somatostatin R2/SSTR2 APC-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Somatostatin R2/SSTR2. Stains SSTR2 transfectants but not irrelevant transfectants in flow cytometry.
Source
Monoclonal Mouse IgG2A Clone # 402038
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
NS0 mouse myeloma cell line transfected with Somatostatin R2/SSTR2
Met1-Ile369
Accession # P30874
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of Somatostatin R2/SSTR2 antibody in HEK293 Human Cell Line Transfected with Human Somatostatin R2/SSTR2 and eGFP antibody by Flow Cytometry. View Larger

Detection of Somatostatin R2/SSTR2 in HEK293 Human Cell Line Transfected with Human Somatostatin R2/SSTR2 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with human Somatostatin R2/SSTR2 and eGFP was stained with Mouse Anti-Human Somatostatin R2/SSTR2 APC-conjugated Monoclonal Antibody (Catalog # FAB4224A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: Somatostatin R2/SSTR2

Somatostatin Receptor 2 (SSTR2) is one of five 7-transmembrane G-protein-coupled receptors for somatostatins 14 and 28. Human SSTR2 shares 84% aa identity with mouse SSTR2 within the extracellular domains. Isoform B (357 aa) has an alternate C-terminal cytoplasmic region that is 12 aa shorter than that of isoform A (369 aa, reported as 93 kDa). Both are expressed in brain, stomach, intestinal epithelia, pancreatic islets and kidney tubules. Isoform B is also expressed in parotid, thyroid and bronchial glands.

Long Name
Somatostatin Receptor Type 2
Entrez Gene IDs
6752 (Human); 20606 (Mouse); 54305 (Rat)
Alternate Names
Smstr2; Somatostatin R2; somatostatin receptor 2; somatostatin receptor type 2; SomatostatinR2; SRIF-1; SS2R; SS-2-R; SS2-R; SST2; SSTR2

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Citations for Human Somatostatin R2/SSTR2 APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy
    Authors: Yogindra Vedvyas, Jaclyn E. McCloskey, Yanping Yang, Irene M. Min, Thomas J. Fahey, Rasa Zarnegar et al.
    Scientific Reports
  2. Development of anti-somatostatin receptors CAR T cells for treatment of neuroendocrine tumors
    Authors: Mandriani B, Pellè E, Mannavola F et al.
    Journal for immunotherapy of cancer
  3. SSTR2 as an anatomical imaging marker and a safety switch to monitor and manage CAR T cell toxicity
    Authors: Y Alcaina, Y Yang, Y Vedvyas, JE McCloskey, MM Jin
    Scientific Reports, 2022-12-03;12(1):20932.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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