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Human SOST/Sclerostin Antibody

Catalog #: MAB1406
14 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB1406-SP
MAB1406-100
MAB1406-500
Product Details
Citations (14)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human SOST/Sclerostin Antibody Summary

Species Reactivity
Human
Specificity
Detects human SOST/Sclerostin in ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse SOST is observed.
Source
Monoclonal Mouse IgG2B Clone # 220902
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human SOST/Sclerostin
Gln24-Tyr213
Accession # Q9BQB4
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human SOST/Sclerostin (Catalog # 1406-ST)

Human SOST Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Human SOST/Sclerostin Biotinylated Antibody (Catalog # BAM14061)

Standard: Recombinant Human SOST/Sclerostin Protein (Catalog # 1406-ST)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SOST/Sclerostin

SOST, also known as sclerostin, belongs to the Cerberus/DAN family of secreted glycoproteins. SOST binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity and functions in bone homeostasis as a BMP antagonist.

Entrez Gene IDs
50964 (Human); 74499 (Mouse)
Alternate Names
sclerostin; SOST; VBCHsclerosteosis

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Citations for Human SOST/Sclerostin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

14 Citations: Showing 1 - 10
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  1. Efficacy of Nerve-Derived Hydrogels to Promote Axon Regeneration Is Influenced by the Method of Tissue Decellularization
    Authors: VK Kuna, A Lundgren, LO Anerillas, P Kelk, M Brohlin, M Wiberg, PJ Kingham, LN Novikova, G Andersson, LN Novikov
    International Journal of Molecular Sciences, 2022-08-06;23(15):.
  2. Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4-weeks of sprint interval training in young men with obesity
    Authors: N Kurgan, H Islam, JBL Matusiak, BJ Baranowski, J Stoikos, VA Fajardo, REK MacPherson, BJ Gurd, P Klentrou
    Physiological Reports, 2022-03-01;10(6):e15232.
  3. Characterization of sclerostin's response within white adipose tissue to an obesogenic diet at rest and in response to acute exercise in male mice
    Authors: N Kurgan, B Baranowski, J Stoikos, AJ MacNeil, VA Fajardo, REK MacPherson, P Klentrou
    Frontiers in Physiology, 2023-01-04;13(0):1061715.
    Species: Mouse
    Sample Types: Protein
    Applications: Western Blot
  4. Icaritin promotes the osteogenesis of bone marrow mesenchymal stem cells via the regulation of sclerostin expression
    Authors: Qiushi Wei, Bin Wang, Hailan Hu, Chuhai Xie, Long Ling, Jianliang Gao et al.
    International Journal of Molecular Medicine
  5. Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis
    Authors: CJM Stapledon, H Tsangari, LB Solomon, DG Campbell, P Hurtado, R Krishnan, GJ Atkins
    PLoS ONE, 2019-09-26;14(9):e0222602.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  6. Sclerostin expression in bone tumours and tumour-like lesions
    Authors: Yusuke Inagaki, Edward S Hookway, Takeshi G Kashima, Mitsuru Munemoto, Yasuhito Tanaka, Andrew Bassim Hassan et al.
    Histopathology
  7. Altered Osteocyte-Specific Protein Expression in Bone after Childhood Solid Organ Transplantation.
    Authors: Pereira R, Valta H, Tumber N, Salusky I, Jalanko H, Makitie O, Wesseling Perry K
    PLoS ONE, 2015-09-21;10(9):e0138156.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  8. Role of Wnt/ beta -catenin and RANKL/OPG in bone healing of diabetic Charcot arthropathy patients
    Authors: Agnetha Folestad, Martin Ålund, Susanne Asteberg, Jesper Fowelin, Ylva Aurell, Jan Göthlin et al.
    Acta Orthopaedica
  9. Osteocytic protein expression response to doxercalciferol therapy in pediatric dialysis patients.
    Authors: Pereira R, Juppner H, Gales B, Salusky I, Wesseling-Perry K
    PLoS ONE, 2015-03-16;10(3):e0120856.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  10. Sclerostin and Dickkopf-1 in Renal Osteodystrophy
    Authors: Daniel Cejka, Johann Herberth, Adam J. Branscum, David W. Fardo, Marie-Claude Monier-Faugere, Danielle Diarra et al.
    Clinical Journal of the American Society of Nephrology
  11. Regulation of circulating sclerostin levels by sex steroids in women and in men.
    Authors: Modder UI, Clowes JA, Hoey K, Peterson JM, McCready L, Oursler MJ, Riggs BL, Khosla S
    J. Bone Miner. Res., 2011-01-01;26(1):27-34.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Development
  12. Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms.
    Authors: Jilka RL, O'Brien CA, Bartell SM, Weinstein RS, Manolagas SC
    J. Bone Miner. Res., 2010-11-01;25(11):2427-37.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  13. Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis.
    Authors: Appel H, Ruiz-Heiland G, Listing J, Zwerina J, Herrmann M, Mueller R, Haibel H, Baraliakos X, Hempfing A, Rudwaleit M, Sieper J, Schett G
    Arthritis Rheum., 2009-11-01;60(11):3257-62.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Development
  14. Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitro.
    Authors: Jager A, Gotz W, Lossdorfer S, Rath-Deschner B
    J. Periodont. Res., 2009-09-23;45(2):246-54.
    Species: Human
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-P, Western Blot

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