Human TACE/ADAM17 Ectodomain Antibody Summary
Pro18-Asn671
Accession # P78536
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TACE/ADAM17
TACE is a member of the ADAM family that contains A Disintegrin And Metalloprotease-like domain. Like other membrane-anchored ADAMs, TACE consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Met-turn expected for reprolysins, a disintegrin-like domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. In addition to its ability to release the 17 kDa extracellular form of tumor necrosis factor-alpha (TNF-alpha ) from the 26 kDa membrane-anchored TNF-alpha, TACE also plays an essential role in shedding ectodomains from a variety of proteins such as L-Selectin, Transforming Growth Factor-alpha, Amyloid Protein Precursor, and Notch-1 receptor. TACE mRNA is present in virtually every tissue and TACE protein resides both on the cell surface and in the cell.
- Black, R.A. and J.D. Becherer (1998) in Tumor Necrosis Factor alpha -Converting Enzyme. Barrett, A.J. et al. (eds): Handbook of Proteolytic Enzymes, San Diego: Academic Press, p. 1315.
- Primakoff, P. and D.G. Myles (2000) Trends in Genetics 16:83.
Product Datasheets
Citations for Human TACE/ADAM17 Ectodomain Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins
Authors: PS Caceres, D Gravotta, PJ Zager, N Dephoure, E Rodriguez-
Proc. Natl. Acad. Sci. U.S.A., 2019-05-29;116(24):11796-11805.
Species: Canine
Sample Types: Cell Lysates
Applications: Western Blot -
The shedding activity of ADAM17 is sequestered in lipid rafts.
Authors: Tellier E, Rebsomen L
Exp. Cell Res., 2006-09-05;312(20):3969-80.
Species: Human, Mouse, Primate - Cholrocebus pygerythrus (Vervet Monkey)
Sample Types: Cell Lysates, Tissue Homogenates
Applications: Western Blot -
FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity.
Authors: Canault M, Tellier E, Bonardo B, Mas E, Aumailley M, Juhan-Vague I, Nalbone G, Peiretti F
J. Cell. Physiol., 2006-08-01;208(2):363-72.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase.
Authors: Ito N, Nomura S, Iwase A, Ito T, Kikkawa F, Tsujimoto M, Ishiura S, Mizutani S
Biochem. Biophys. Res. Commun., 2004-02-20;314(4):1008-13.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
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