Human TAPP1 Antibody

Catalog #: MAB4039 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB4039
MAB4039-SP

All TAPP1 Antibodies

Product Details

Supplemental Products

Reviews

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human TAPP1 Antibody Summary

Species Reactivity

Human

Specificity

Detects human TAPP1 in direct ELISAs and Western blots.

Source

Monoclonal Rat IgG_2A Clone # 376409

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

E. coli-derived recombinant human TAPP1
Pro2-Val404
Accession # Q9HB21

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human TAPP1

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TAPP1

TAPP1, gene name PLEKHA1 (pleckstrin homology family A, member 1) is a 70‑75 kDa cytoplasmic adaptor protein that is membrane-associated after binding of the phosphoinositide, PtdIns(3,4)P2. The 404 aa human TAPP1 shares 76% aa identity with mouse TAPP1. It is expressed most highly in skeletal muscle, spleen, lung, thymus and placenta. TAPP1 interacts with cytoskeletal syntrophins, colocalizing in membrane ruffles following PDGF treatment in transfected NIH‑3T3 cells. TAPP1 and the related TAPP2 appear to play a role in B and T cell activation.

Long Name

Tandem PH Domain Containing Protein 1

Entrez Gene IDs

59338 (Human); 101476 (Mouse); 361659 (Rat)

Alternate Names

family A (phosphoinositide bindingspecific) member 1; PH domain-containing family A member 1; pleckstrin homology domain containing, family A (phosphoinositide bindingspecific) member 1; PLEKHA1; TAPP1