Human TGF-beta RIII PE-conjugated Antibody Summary
Gly21-Asp781
Accession # AAA67061
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TGF‑ beta RIII in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Goat Anti-Human TGF-beta RIII PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB242P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of TGF‑ beta RIII in Human MCF-7 Cell Line by Flow Cytometry MCF-7 human breast adenocarcinoma cell line was stained with Goat Anti-Human TGF-beta RIII PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB242P, filled histogram) or isotype control antibody (IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TGF-beta RIII
Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta.
The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction. The Type III receptor binds TGF-beta 2 with the highest affinity. Other TGF-beta isoforms also bind the Type III receptor, but with lower affinities. Cellular responsiveness to TGF-beta 2 appears to be dependent on the presence of the Type III receptor which can interact with the signaling receptor complex. In addition to the transmembrane Type III receptor, a soluble form of the receptor is secreted by some cell types. The physiological role of this soluble receptor remains to be determined. The recombinant TGF-beta soluble receptor Type III binds the TGF-beta isoforms differentially in solution and exhibits TGF-beta antagonistic activities in vitro.
Product Datasheets
Citations for Human TGF-beta RIII PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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Role of gastric epithelial cell-derived transforming growth factor beta in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection
Authors: Ellen J. Beswick, Iryna V. Pinchuk, Rachel B. Earley, David A. Schmitt, Victor E. Reyes
Infection and Immunity
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Modulation of cerebral endothelial cell function by TGF-beta in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition
Authors: Shanmugarajan Krishnan, Emese Szabo, Isabel Burghardt, Karl Frei, Ghazaleh Tabatabai, Michael Weller
Oncotarget
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Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells
Authors: S Stephenson, MA Care, I Fan, A Zougman, DR Westhead, GM Doody, RM Tooze
J. Immunol., 2019-01-14;202(4):1287-1300.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Biomarkers on melanoma patient T cells associated with ipilimumab treatment.
Authors: Wang W, Yu D, Sarnaik A, Yu B, Hall M, Morelli D, Zhang Y, Zhao X, Weber J
J Transl Med, 2012-07-12;10(0):146.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
The miR-200c/141-ZEB2-TGF beta axis is aberrant in human T-cell prolymphocytic leukemia
Authors: Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. Van de Werken, Leticia G. Leon et al.
Haematologica
FAQs
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What epitope does this antibody detect?
We have not done epitope mapping, but the antibody was raised against the extracellular domain of recombinant human TGF -beta RIII, Gly 21-Asp781, accession # AAA67061. The antibody will react with the antigen in this region.
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