Human Thrombomodulin/BDCA-3 (NP_000352) VersaClone cDNA

Human Thrombomodulin/BDCA-3 (NP_000352) VersaClone cDNA Summary

Specifications

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Background: Thrombomodulin/BDCA-3

Thrombomodulin (TM), also known as CD141 and BDCA3, is a transmembrane expressed on vascular endothelial cells (EC), arterial smooth muscle cells, monocytes, and macrophages. It binds Thrombin and enhances the Thrombin-mediated activation of the anti-coagulant Protein C and the anti-fibrinolytic TAFI/Carboxypeptidase B2. Thrombomodulin also inhibits the ability of Thrombin to activate several pro-coagulant proteins (e.g. Fibrinogen, Factor V, Factor XIII, PAR-1). Thrombomodulin exerts multiple anti-inflammatory effects and reduces the severity of disease involving chronic inflammation. In cancer, Thrombomodulin suppresses tumor angiogenesis, growth, and epithelial-mesenchymal transition. Soluble fragments of Thrombomodulin are elevated in the serum, urine, and synovial fluid during coagulation disorders, inflammation, and organ failure.

Related Research Areas

• Coagulation
• Conventional/Classical Dendritic Cells
• Endothelial Cell Coagulation Molecules
• Endothelial Cell Markers
• Monocyte Markers
• Multiple Sclerosis and Myelin Related Molecules
• Neutrophils
• Preeclampsia
• Serine Proteases and Regulators