Human Thymopoietin Biotinylated Antibody

Catalog #: BAF843 Datasheet / COA / SDS

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BAF843

All Thymopoietin Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Thymopoietin Biotinylated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Thymopoietin in Western blots.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human Thymopoietin
Pro2-Gln187

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Label

Biotin

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human Thymopoietin

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Thymopoietin

Thymopoietin (TP alpha; also TMPO, LAP2 alpha and TPRP alpha ) is a 75 kDa member of the LEM family of molecules. It is a nucleoplasmic protein that is widely expressed in cells such as keratinocytes and thymocytes. Here, it interacts with A-type lamins and Rb/retinoblastoma protein, thus participating in cell cycle exit. Human thymopoietin is 694 amino acids (aa) in length. It contains a potential N-terminal “thymopoietin peptide” segment (aa #2-49), a BAF-binding LEM domain (aa #109-153), an NLS (aa #190-196), and a coiled-coil region (aa #558-657). Multiple splice variants exist. All contain the same 188 N-terminal amino acids. Five variants show singular 49, 157, 266, 226, and 60 aa substitutions for the C-terminal 506 amino acids. Over aa #2-187, human thymopoietin shares 93% aa identity with mouse thymopoietin.

Entrez Gene IDs

7112 (Human)

Alternate Names

CMD1T; lamina-associated polypeptide 2; LAP2PRO0868; LEM domain containing 4; LEMD4; MGC61508; Thymopoietin isoform alpha; Thymopoietin; Thymopoietin, isoforms beta/gamma; Thymopoietin-related peptide isoform alpha; Thymopoietin-related peptide isoforms beta/gamma; TMPO; TP alpha; TP beta/gamma; TP; TPRP isoform alpha; TPRP isoforms beta/gamma