Human TRANCE/TNFSF11/RANK L APC-conjugated Antibody Summary
Gly64-Asp245
Accession # AAC51762
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TRANCE/TNFSF11/RANK L in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) treated with PHA for were stained with Mouse Anti-Human IL-2 Ra PE-conjugated Monoclonal Antibody (Catalog # FAB1020P) and either (A) Mouse Anti-Human TRANCE/TNFSF11/RANK L APC-conjugated Monoclonal Antibody (Catalog # FAB6264A) or (B) Mouse IgG2BAllophycocyanin Isotype Control (Catalog # IC0041A). View our protocol for Staining Membrane-associated Proteins.
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Detection of TRANCE/TNFSF11/RANK L in NTERA2 cell line by Flow Cytometry. Human NTERA2 embryonal carcinoma cell line was stained with Mouse Anti-Human TRANCE/TNFSF11/RANK L APC-conjugated Monoclonal Antibody (Catalog # FAB6264A, filled histogram) or Mouse IgG2B Allophycocyanin Isotype Control (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of TRANCE/TNFSF11/RANK L in HEK293 human cell line transfected with human TRANCE by Flow Cytometry. Human HEK293 cell line transfected with human TRANCE was stained with Mouse Anti-Human TRANCE/TNFSF11/RANK L APC-conjugated Monoclonal Antibody (Catalog # FAB6264A, filled histogram) or Mouse IgG2B Allophycocyanin Isotype Control (Catalog # IC0041A, open histogram).View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TRANCE/TNFSF11/RANK L
TNF-related activation-induced cytokine (TRANCE; also RANK L, OPGL, and ODF) is a 35 kDa (predicted) type II transmembrane glycoprotein and member of the TNF cytokine family. Human TRANCE is 317 amino acids (aa) in length and contains a 47 aa cytoplasmic region, a 21 aa transmembrane region, and a 249 extracellular domain (ECD), which contains two potential sites of N-linked glycosylation. Splicing variants produce three isoforms for human TRANCE. Isoform 1 is the standard form. In isoform 2, aa corresponding to 1-73 in isoform 1 are missing. In isoform 3, aa 1-47 are missing. Human TRANCE ECD is 83% identical to mouse TRANCE ECD. TRANCE is expressed highest in the peripheral lymph nodes and weaker in the spleen, peripheral blood leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach, and thyroid. TRANCE plays a role in osteoclast differentiation and activation.
Product Datasheets
Citation for Human TRANCE/TNFSF11/RANK L APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Increased level of cell-derived microparticles in the cyst fluids of odontogenic keratocysts
Authors: Qi-Wen Man, Wen-Qun Zhong, Jian-Gang Ren, Jin-Yuan Liu, Yue-Yu Zheng, Rui-Fang Li et al.
International Journal of Oncology
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