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Human Transthyretin/Prealbumin Antibody

Catalog #: MAB7505
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB7505
MAB7505-SP
Detection of Human Transthyretin/Prealbumin by Western Blot.
2 Images
Product Details
Citations (4)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Transthyretin/Prealbumin Antibody Summary

Species Reactivity
Human
Specificity
Detects human Transthyretin/Prealbumin in direct ELISAs and Western blots.
Source
Monoclonal Mouse IgG1 Clone # 760430
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human Transthyretin/Prealbumin
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
2 µg/mL
See below
Immunocytochemistry
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human Transthyretin/Prealbumin antibody by Western Blot. View Larger

Detection of Human Transthyretin/Prealbumin by Western Blot. Western blot shows human plasma. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Transthyretin/Prealbumin Monoclonal Antibody (Catalog # MAB7505) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Transthyretin/Prealbumin at approximately 15 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry Transthyretin/Prealbumin antibody in HepG2 Human Cell Line by Immunocytochemistry (ICC). View Larger

Transthyretin/Prealbumin in HepG2 Human Cell Line. Transthyretin/Prealbumin was detected in immersion fixed HepG2 human hepatocellular carcinoma cell line using Mouse Anti-Human Transthyretin/ Prealbumin Monoclonal Antibody (Catalog # MAB7505) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Sterile PBS to a final concentration of 0.5 mg/mL.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Transthyretin/Prealbumin

Transthyretin (TTR), previously called thyroxin-binding prealbumin, is a 55 kDa homotetramer of 14-15 kDa monomers that is found in plasma. TTR is responsible for the transport of the thyroid hormone T4 and retinol binding protein (RBP). It slows renal clearance of T4 and RBP due to megalin-mediated re-uptake of TTR complexes in the renal tubules. TTR is also found in tissues including the brain. Numerous human polymorphisms have been associated with aggregates found in familial amyloidotic polyneuropathies (FAP). Mature human TTR shares 80% and 83% amino acid sequence identity with mouse and rat TTR, respectively.

Entrez Gene IDs
7276 (Human)
Alternate Names
ATTR; HsT2651; PALB; PALBTBPA; Prealbumin; prealbumin, amyloidosis type I; TBPA; thyroxine-binding prealbumin; Transthyretin; TTR

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Citations for Human Transthyretin/Prealbumin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Bottom-up approach to deciphering the targets of the ubiquitin-proteasome system in porcine sperm capacitation
    Authors: Zigo, M;Netherton, J;Zelenková, N;Kerns, K;Kraus, V;Postlerová, P;Baker, M;Sutovsky, P;
    Scientific reports
    Species: Porcine
    Sample Types: Sperm
    Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
  2. Construction and Evaluation of a Novel MAP Immunoassay for 9 Nutrition-and-Health-Related Protein Markers Based on Multiplex Liquid Protein Chip Technique
    Authors: Yin J, Niu J, Huo J et al.
    Nutrients
  3. Construction and Evaluation of a Novel MAP Immunoassay for 9 Nutrition-and-Health-Related Protein Markers Based on Multiplex Liquid Protein Chip Technique
    Authors: Yin J, Niu J, Huo J et al.
    Nutrients
  4. Microglia innate immune response contributes to the antiviral defense and blood-CSF barrier function in human choroid plexus organoids during HSV-1 infection
    Authors: Qiao H, Chiu Y, Liang X et al.
    Journal of medical virology

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