Human Trefoil Factor 3 Antibody Summary
Ala21-Phe80
Accession # Q07654
Applications
under non-reducing conditions only
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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TFF3 in Human Colon. TFF3 was detected in immersion fixed paraffin-embedded sections of human colon using 25 µg/mL Human TFF3 Monoclonal Antibody (Catalog # MAB4407) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of goblet cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TFF3
Trefoil Factor 3 (TFF3) is one of three trefoil peptides secreted by epithelial cells that line mucus membranes. Trefoils contribute to protection and repair of the gastrointestinal tract. TFF3 is secreted by mucus-producing goblet cells in the large and small intestines and lower respiratory tract. It is mainly active as a disulfide-linked homodimer. The mature 59 aa, 6.5 kDa human TFF3 contains one trefoil structure formed by intramolecular disulfides and shows 76% aa identity with mouse TFF3.
Product Datasheets
Citations for Human Trefoil Factor 3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That Support BRAF-Mutant Colorectal Cancer
Authors: Samuel A. Miller, Robert A. Policastro, Shruthi Sriramkumar, Tim Lai, Thomas D. Huntington, Christopher A. Ladaika et al.
Cancer Research
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Expression of trefoil factor 3 is decreased in colorectal cancer
Authors: Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy, Charulochana Subramony, Marcelo Sakiyama et al.
Oncology Reports
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Non-endoscopic screening biomarkers for Barrett's oesophagus: from microarray analysis to the clinic.
Authors: Lao-Sirieix P, Boussioutas A, Kadri SR, O'Donovan M, Debiram I, Das M, Harihar L, Fitzgerald RC
Gut, 2009-08-02;58(11):1451-9.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Trefoil factor 3: a novel serum marker identified by gene expression profiling in high-grade endometrial carcinomas.
Authors: Bignotti E, Ravaggi A, Tassi RA, Calza S, Rossi E, Falchetti M, Romani C, Bandiera E, Odicino FE, Pecorelli S, Santin AD
Br. J. Cancer, 2008-09-02;99(5):768-73.
Species: Human
Sample Types: Serum
Applications: ELISA Development
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Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma
