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Human ULBP-3 Antibody

Catalog #: MAB15171
7 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB15171
MAB15171-SP
Product Details
Citations (7)
FAQs
Supplemental Products
Reviews (1)
Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human ULBP-3 Antibody Summary

Species Reactivity
Human
Specificity
Detects human ULBP-3 in direct ELISAs and Western blots. In these formats, this antibody does not cross‑react with recombinant human (rh) ULBP-1 or rhULBP-2.
Source
Monoclonal Mouse IgG2A Clone # 166514
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
BaF3 mouse pro-B cell line transfected with human ULBP-3
Accession # Q9BZM4
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human ULBP‑3 Fc Chimera (Catalog # 1517-UL)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ULBP-3

ULBP-3 is a GPI-linked cell-surface protein that functions as a ligand for human NKG2D. ULBP-1, -2, and -3 are expressed on some tumor cells and have been implicated in immune surveillance of tumors. Unlike ULBP-1 and -2, ULBP-3 does not interact with the CMV glycoprotein UL16.

Long Name
UL16 Binding Protein-3
Entrez Gene IDs
79465 (Human)
Alternate Names
NKG2D ligand 3; RAET1N; UL16 binding protein 3; ULBP3; ULBP-3

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Citations for Human ULBP-3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. Targeting the Epidermal Growth Factor Receptor Can Counteract the Inhibition of Natural Killer Cell Function Exerted by Colorectal Tumor-Associated Fibroblasts
    Authors: Costa D, Vene R, Benelli R et al.
    Front Immunol
  2. The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing
    Authors: E Seidel, L Dassa, C Schuler, E Oiknine-Dj, DG Wolf, VTK Le-Trillin, O Mandelboim
    PloS Pathogens, 2021-05-03;17(5):e1008807.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
    Authors: E Seidel, L Dassa, S Kahlon, B Tirosh, A Halenius, T Seidel Mal, O Mandelboim
    Nature Communications, 2021-04-06;12(1):2061.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D
    Authors: M Diab, D Schmiedel, E Seidel, E Bacharach, O Mandelboim
    Viruses, 2020-07-20;12(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate.
    Authors: Poggi A, Catellani S, Garuti A, Pierri I, Gobbi M, Zocchi MR
    Leukemia, 2009-01-08;23(4):641-8.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Development
  6. High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas
    Authors: Maria Raffaella Zocchi, Silvia Catellani, Paolo Canevali, Sara Tavella, Anna Garuti, Barbara Villaggio et al.
    Blood
  7. The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition
    Authors: Abigael Eva Chaouat, Barbara Seliger, Ofer Mandelboim, Dominik Schmiedel
    Frontiers in Immunology

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Human ULBP-3 Antibody
By Marry Tahani on 11/16/2018
Application: B/N Sample Tested: Pancreatic cancer cells Species: Mouse