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Human VEGFR1/Flt-1 DuoSet ELISA

Catalog #: DY321
26 Citations Datasheet / COA / SDS

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DY321 has been discontinued.
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Human VEGF R1 / Flt-1 ELISA Standard Curve
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Citations (26)
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Human VEGFR1/Flt-1 DuoSet ELISA Summary

Assay Range
156.0 - 10,000 pg/mL
Specificity
Please see the product datasheet

* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.

Scientific Data

N/A Human VEGF R1 / Flt-1 ELISA Standard Curve View Larger

Human VEGF R1 / Flt-1 ELISA Standard Curve

Product Datasheets

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Product Datasheet
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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: VEGFR1/Flt-1

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.

Long Name:
Vascular Endothelial Growth Factor Receptor 1
Entrez Gene IDs:
2321 (Human); 14254 (Mouse)
Alternate Names:
EC 2.7.10; EC 2.7.10.1; FLT; FLT1; Flt-1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor); FRT; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; Vascular permeability factor receptor; VEGF R1; VEGFR1; VEGFR-1

Citations for Human VEGFR1/Flt-1 DuoSet ELISA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

26 Citations: Showing 1 - 10
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  1. Hydroxychloroquine reduces soluble Flt-1 secretion from human cytotrophoblast, but does not mitigate markers of endothelial dysfunction in vitro
    Authors: E Kadife, N Hannan, A Harper, N Binder, S Beard, FC Brownfoot
    PLoS ONE, 2022-11-23;17(11):e0271560.
    Species: Human
    Sample Types: Cell Culture Supernates
  2. Serum Collected from Preeclamptic Pregnancies Drives Vasoconstriction of Human Omental Arteries-A Novel Ex Vivo Model of Preeclampsia for Therapeutic Development
    Authors: BR Fato, N de Alwis, S Beard, NK Binder, N Pritchard, S Tong, TJ Kaitu'u-Li, NJ Hannan
    International Journal of Molecular Sciences, 2022-09-16;23(18):.
    Species: Human
    Sample Types: Serum
  3. No association between intravenous fluid volume and endothelial glycocalyx shedding in patients undergoing resuscitation for sepsis in the emergency department
    Authors: S Macdonald, E Bosio, NI Shapiro, L Balmer, S Burrows, M Hibbs, T Jowitt, L Smart, G Arendts, D Fatovich
    Scientific Reports, 2022-05-24;12(1):8733.
    Species: Human
    Sample Types: Serum
  4. A prospective cohort study providing insights for markers of adverse pregnancy outcome in older mothers
    Authors: SC Lean, RL Jones, SA Roberts, AEP Heazell
    BMC pregnancy and childbirth, 2021-10-20;21(1):706.
    Species: Human
    Sample Types: Serum
  5. NR4A2 expression is not altered in placentas from cases of growth restriction or preeclampsia, but is reduced in hypoxic cytotrophoblast
    Authors: N de Alwis, S Beard, NK Binder, N Pritchard, TJ Kaitu'u-Li, SP Walker, O Stock, KM Groom, S Petersen, A Henry, JM Said, S Seeho, SC Kane, S Tong, NJ Hannan
    Scientific Reports, 2021-10-19;11(1):20670.
    Species: Human
    Sample Types: Cell Culture Supernates
  6. Megalin, Proton Pump Inhibitors and the Renin-Angiotensin System in Healthy and Pre-Eclamptic Placentas
    Authors: Y Sun, L Tan, RI Neuman, M Broekhuize, S Schoenmake, X Lu, AHJ Danser
    International Journal of Molecular Sciences, 2021-07-10;22(14):.
    Species: Human
    Sample Types: Cell Culture Supernates
  7. Identifying potential biomarkers related to pre-term delivery by proteomic analysis of amniotic fluid
    Authors: S Hong, JE Lee, YM Kim, Y Park, JW Choi, KH Park
    Sci Rep, 2020-11-12;10(1):19648.
    Species: Human
    Sample Types: Amniotic Fluid
  8. TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies
    Authors: LM Gierman, GB Silva, Z Pervaiz, JJ Rakner, SB Mundal, AJ Thaning, I Nervik, M Elschot, S Mathew, LCV Thomsen, L Bjørge, AC Iversen
    J. Leukoc. Biol., 2020-06-23;0(0):.
    Species: Human
    Sample Types: Placental Supernates
  9. Differential regulation of sFlt-1 splicing by U2AF65 and JMJD6 in placental-derived and endothelial cells
    Authors: AC Eddy, H Chapman, DT Brown, EM George
    Biosci. Rep., 2020-02-28;40(2):.
    Species: Human
    Sample Types: Cell Culture Supernates
  10. No association between early antiretroviral therapy during pregnancy and plasma levels of angiogenic factors: a cohort study
    Authors: A Djeha, S Girard, H Trottier, F Kakkar, H Soudeyns, M Boucher, N Lapointe, I Boucoiran
    BMC Pregnancy Childbirth, 2019-12-09;19(1):482.
    Species: Human
    Sample Types: Serum
  11. Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction
    Authors: FC Brownfoot, NJ Hannan, P Cannon, V Nguyen, R Hastie, LJ Parry, S Senadheera, L Tuohey, S Tong, TJ Kaitu'u-Li
    EBioMedicine, 2019-02-26;0(0):.
    Species: Human
    Sample Types: Tissue Culture Supernates
  12. Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia
    Authors: NJ Hannan, NK Binder, S Beard, TV Nguyen, TJ Kaitu'u-Li, S Tong
    PLoS ONE, 2018-04-11;13(4):e0187082.
    Species: Human
    Sample Types: Cell Culture Supernates
  13. Combinations of Bevacizumab and Erlotinib show activity in colorectal cancer independent of RAS status
    Authors: P Mésange, A Bouygues, N Ferrand, M Sabbah, AE Escargueil, A Savina, B Chibaudel, C Tournigand, T Andre, A de Gramont, AK Larsen
    Clin. Cancer Res., 2018-02-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
  14. Placental Dysfunction Underlies Increased Risk of Fetal Growth Restriction and Stillbirth in Advanced Maternal Age Women
    Authors: SC Lean, AEP Heazell, MR Dilworth, TA Mills, RL Jones
    Sci Rep, 2017-08-29;7(1):9677.
    Species: Human
    Sample Types: Serum
  15. Effect of selective small molecule inhibitors on MMP-9 and VEGFR-1 expression in p16-positive and -negative squamous cell carcinoma
    Authors: B Kramer, JD Schultz, C Hock, A Sauter, BA Stuck, K Hörmann, R Birk, C Aderhold
    Oncol Lett, 2017-03-13;13(5):3269-3276.
    Species: Human
    Sample Types: Cell Culture Supernates
  16. Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania
    PLoS ONE, 2016-12-09;11(12):e0167716.
    Species: Human
    Sample Types: Plasma
  17. Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors.
    Authors: Kumar N, Moideen K, Sivakumar S, Menon P, Viswanathan V, Kornfeld H, Babu S
    J Infect, 2016-10-04;74(1):10-21.
    Species: Human
    Sample Types: Plasma
  18. Circulating Angiogenic Factors as Biomarkers of Disease Severity and Bacterial Burden in Pulmonary Tuberculosis.
    Authors: Kumar N, Banurekha V, Nair D, Babu S
    PLoS ONE, 2016-01-04;11(1):e0146318.
    Species: Human
    Sample Types: Plasma
  19. Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women.
    Authors: McDonald C, Darling A, Conroy A, Tran V, Cabrera A, Liles W, Wang M, Aboud S, Urassa W, Fawzi W, Kain K
    PLoS ONE, 2015-08-06;10(8):e0134619.
    Species: Human
    Sample Types: Plasma
  20. Host biomarkers distinguish dengue from leptospirosis in Colombia: a case-control study.
    Authors: Conroy A, Gelvez M, Hawkes M, Rajwans N, Liles W, Villar-Centeno L, Kain K
    BMC Infect Dis, 2014-01-20;14(0):35.
    Species: Human
    Sample Types: Serum
  21. Differential expression of Vegfr-2 and its soluble form in preeclampsia.
    Authors: Munaut C, Lorquet S, Pequeux C, Coulon C, Le Goarant J, Chantraine F, Noel A, Goffin F, Tsatsaris V, Subtil D, Foidart JM
    PLoS ONE, 2012-03-12;7(3):e33475.
    Species: Human
    Sample Types: Plasma
  22. Serum concentrations of soluble Flt-1 are decreased among women with a viable fetus and no symptoms of miscarriage destined for pregnancy loss.
    Authors: Kaitu'u-Lino TJ, Whitehead CL, Ngian GL, Permezel M, Tong S
    PLoS ONE, 2012-02-28;7(2):e32509.
    Species: Human
    Sample Types: Serum
  23. Performance characteristics of combinations of host biomarkers to identify women with occult placental malaria: a case-control study from Malawi.
    Authors: Conroy AL, Liles WC, Molyneux ME
    PLoS ONE, 2011-12-12;6(12):e28540.
    Species: Human
    Sample Types: Plasma
  24. Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study.
    Authors: Erdman LK, Dhabangi A, Musoke C, Conroy AL, Hawkes M, Higgins S, Rajwans N, Wolofsky KT, Streiner DL, Liles WC, Cserti-Gazdewich CM, Kain KC
    PLoS ONE, 2011-02-25;6(2):e17440.
    Species: Human
    Sample Types: Plasma
  25. Secretion of angiogenic growth factors by villous cytotrophoblast and extravillous trophoblast in early human pregnancy.
    Authors: Lash GE, Naruse K, Innes BA, Robson SC, Searle RF, Bulmer JN
    Placenta, 2010-03-24;31(6):545-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  26. Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.
    Authors: Kishuku M, Nishioka Y, Abe S, Kishi J, Ogino H, Aono Y, Azuma M, Kinoshita K, Batmunkh R, Rentsenhand B, Makino H, Ranjan P, Minakuchi K, Sone S
    J. Immunol., 2009-12-15;183(12):8176-85.
    Species: Human
    Sample Types: Cell Culture Supernates

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