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Human XCL1/Lymphotactin Antibody

Catalog #: MAB6951
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB6951
MAB6951-SP
Product Details
Citations (6)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human XCL1/Lymphotactin Antibody Summary

Species Reactivity
Human
Specificity
Detects human XCL1/Lymphotactin in ELISAs and Western blots. In sandwich ELISAs, less than 0.15% cross-reactivity was observed with recombinant mouse MCP‑5, recombinant human (rh) MIP‑3 beta, rhGRO alpha, rhTGF‑ alpha, rhGRO gamma, rhActivin RII Fc Chimera, rhIGF‑II, or rhIL‑15.
Source
Monoclonal Mouse IgG1 Clone # 109001
Purification
Protein A or G purified from ascites
Immunogen
E. coli-derived recombinant human XCL1/Lymphotactin
Val22-Gly114
Accession # P47992
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human XCL1/Lymphotactin (Catalog # 695-LT)

Human XCL1/Lymphotactin Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Human XCL1/Lymphotactin Biotinylated Antibody (Catalog # BAF695)

Standard: Recombinant Human XCL1/Lymphotactin Protein (Catalog # 695-LT)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: XCL1/Lymphotactin

Human lymphotactin (Lptn)/XCL1 (also named human SCM-1 alpha and ATAC) and its mouse homologue belong to the C or gamma  subfamily of chemokines. The C chemokines lack two (the 1st and 3rd ) of the four invariant cysteine residues normally found in the CC and CXC chemokines and have an extended carboxy terminus. Human lymphotactin encodes a 114 amino acid residue precursor protein with a 21 amino acid residue predicted signal peptide. The expression of lymphotactin is abundant in some activated T cells such as activated CD8+ T cells and other class I MHC restricted T cells. Lptn expression is absent in CD4+ T cells. Human and mouse Lptn share approximately 60% amino acid sequence homology. The gene for lymphotactin has been mapped to chromosome 1 in both human and mouse. Recombinant human lymphotactin has been shown to have chemotactic activity for lymphocytes and NK cells. The orphan receptor GPR5 has been reported to be the specific receptor for Lptn.

References
  1. Kennedy, J. et al. (1995) J. Immunol. 155:203.
  2. Zlotnik, A. et al. (1999) Critical Reviews in Immunol. 19:1.
Long Name
Chemokine [C Motif] Ligand 1
Entrez Gene IDs
6375 (Human); 16963 (Mouse)
Alternate Names
ATAC; ATACSmall-inducible cytokine C1; C motif chemokine 1; chemokine (C motif) ligand 1; Cytokine SCM-1; LPTNSCM-1-alpha; LTNXC chemokine ligand 1; Lymphotactin; lymphotaxin; SCM-1 alpha; SCM-1; SCM1A; SCM-1a; SCYC1SCM1; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); XCL1

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Citations for Human XCL1/Lymphotactin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer
    Authors: Bérengère Salomé, John P. Sfakianos, Daniel Ranti, Jorge Daza, Christine Bieber, Andrew Charap et al.
    Cancer Cell
  2. Deep spatial profiling of COVID19 brains reveals neuroinflammation by compartmentalized local immune cell interactions and targets for intervention
    Authors: Schwabenland M, SaliE H, Tanevski J et al.
    Immunity
  3. Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy
    Authors: Li, Q;Sharkey, A;Sheridan, M;Magistrati, E;Arutyunyan, A;Huhn, O;Sancho-Serra, C;Anderson, H;McGovern, N;Esposito, L;Fernando, R;Gardner, L;Vento-Tormo, R;Turco, MY;Moffett, A;
    Cell stem cell
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  4. Targeting Influenza Virus Hemagglutinin to Xcr1(+) Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses
    Authors: A Gudjonsson, A Lysén, S Balan, V Sundvold-G, C Arnold-Sch, L Richter, ES Bækkevold, M Dalod, B Bogen, E Fossum
    J. Immunol, 2017-02-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  5. The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1.
    Authors: Guzzo C, Fox J, Lin Y, Miao H, Cimbro R, Volkman B, Fauci A, Lusso P
    PLoS Pathog, 2013-12-26;9(12):e1003852.
    Species: Virus - HIV-1
    Sample Types: Virus
    Applications: Capture Assay
  6. Mycobacterium tuberculosis antigen Wag31 induces expression of C-chemokine XCL2 in macrophages.
    Authors: Cao W, Tang S, Yuan H, Wang H, Zhao X, Lu H
    Curr. Microbiol., 2008-07-11;57(3):189-94.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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