Hygromycin B
Chemical Name: O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
Purity: ≥90%
Biological Activity
Hygromycin B is an aminoglycoside antibiotic. Active against both prokaryotic and eukaryotic cells. Inhibits protein synthesis by binding to the 30S subunit and inhibiting the ribosomal translocation step of elongation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eukaryotic cells.
Blochlinger and Diggelmann
Mol.Cell.Biol., 1984;4:2929 -
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Brodersen et al.
Cell, 2000;103:1143 -
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes.
Ganoza and Kiel
Antimicrob.Agents Chemother., 2001;45:2813
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