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I 432

Catalog #: 7292 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7292/5
I 432 | CAS No. 1268874-09-4 | TMPRSS2
1 Image
Description: TMPRSS2 Inhibitor

Chemical Name: 3-[(2S)-3-[4-(2-Aminoethyl)-1-piperidinyl]-2-[[(2',4'-dichloro[1,1'-biphenyl]-3-yl)sulfonyl]amino]-3-oxopropyl]benzenecarboximidamide ditrifluoroacetate

Purity: ≥98%

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Biological Activity

I 432 is a TMPRSS2 (transmembrane serine proteinase 2) inhibitor (Ki =0.9 nM). It blocks influenza virus propagation in airway epithelial cells. In IPEC-J2 pig jejunal epithelial cells, I 432 (50 μM) inhibits TMPRSS2 without affecting cell viability after 48 h treatment.

Technical Data

M.Wt:
830.62
Formula:
C29H33Cl2N5O3S.2CF3CO2H
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1268874-09-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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