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Ibotenic acid

Catalog #: 0285
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0285/5
Ibotenic acid | CAS No. 2552-55-8 | NMDA Receptor Agonists
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Description: NMDA agonist; also non selective mGlu agonist

Chemical Name: α-Amino-(3-hydroxy-5-isoxazolyl)acetic acid

Purity: ≥98%

Product Details
Citations (4)
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Biological Activity

Ibotenic acid is a NMDA and metabotropic glutamate receptor agonist.

Technical Data

M.Wt:
158.11
Formula:
C5H6N2O4
Solubility:
Soluble to 10 mM in water and to 100 mM in 1.1eq. NaOH
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2552-55-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Enhanced consumption of salient solutions following pedunculopontine tegmental lesions.
    MacLaren D, Markovic T, Daniels D, Clark S
    Neuroscience, 2015;284(0):381-99.
  3. Central actions of ibotenic acid and muscimol.
    Johnston et al.
    Biochem.Pharmacol., 1968;17:2488
  4. Molecular diversity of glutamate receptors and implications for brain functions.
    Nakanishi
    Science, 1992;258:597
  5. The metabotropic glutamate receptors: structure and functions.
    Pin and Duvoisin
    Neuropharmacology, 1995;34:1
  6. Excitatory amino acid transmitters.
    Watkins and Evans
    Annu.Rev.Pharmacol.Toxicol., 1981;21:165

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Citations for Ibotenic acid

The citations listed below are publications that use Tocris products. Selected citations for Ibotenic acid include:

4 Citations: Showing 1 - 4

  1. Role of Prefrontal Cortex Anti- and Pro-inflammatory Cytokines in the Development of Abnormal Behaviors Induced by Disconnection of the Ventral Hippocampus in Neonate Rats.
    Authors: Joseph Et al.
    Front Behav Neurosci  2018;12:244
  2. The supramammillary nucleus and the claustrum activate the cortex during REM sleep.
    Authors: Renouard Et al.
    Neurobiol Learn Mem  2015;1:e1400177
  3. Exaggerated cue-induced reinstatement of cocaine seeking but not incubation of cocaine craving in a developmental rat model of schizophrenia.
    Authors: Karlsson Et al.
    Psychopharmacology (Berl)  2013;226:45
  4. The central amygdala nucleus via corticotropin-releasing factor is necessary for time-limited consolidation processing but not storage of contextual fear memory.
    Authors: Pitts and Takahashi
    Neuroreport  2011;95:86

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