Home / Voltage-gated Potassium Channel Activators / ICA 069673

ICA 069673

Catalog #: 4305
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4305/25
4305/5
ICA 069673 | CAS No. 582323-16-8 | Voltage-gated Potassium Channel Activators
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Description: KV7.2/KV7.3 channel opener

Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

Technical Data

M.Wt:
269.63
Formula:
C11H6ClF2N3O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
582323-16-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ICA 069673

The citations listed below are publications that use Tocris products. Selected citations for ICA 069673 include:

3 Citations: Showing 1 - 3

  1. Lucanthone, a potential PPT1 inhibitor, perturbs stemness, reduces tumor microtube formation and slows the growth of temozolomide-resistant gliomas in vivo.
    Authors: Radin Et al.
    J.Pharmacol.Exp.Ther.  2024;
  2. Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine.
    Authors: Vicente-Baz Et al.
    Neuropharmacology  2016;109:131
  3. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.
    Authors: Brueggemann Et al.
    Mol.Pharmacol.  2014;2014:330

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