Home / Voltage-gated Sodium Channel Blockers / ICA 121431

ICA 121431

Catalog #: 5066
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5066/10
5066/50
ICA 121431 | CAS No. 313254-51-2 | Voltage-gated Sodium Channel Blockers
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Description: Potent and selective NaV1.3 and NaV1.1 channel blocker

Chemical Name: α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ICA 121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50 values are >10 μM for human NaV1.5 and NaV1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.

Technical Data

M.Wt:
449.55
Formula:
C23H19N3O3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
313254-51-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
    McCormack et al.
    Proc.Natl.Acad.Sci., 2013;110:2724

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Citations for ICA 121431

The citations listed below are publications that use Tocris products. Selected citations for ICA 121431 include:

3 Citations: Showing 1 - 3

  1. NaV1.1 is essential for proprioceptive signaling and motor behaviors.
    Authors: Darik A Et al.
    Elife  2022;11
  2. Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons.
    Authors: Ellen A Et al.
    J Neurosci  2019;39:7086-7101
  3. Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves.
    Authors: Kocmalova Et al.
    J Pharmacol Exp Ther  2017;361:172

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