Home / Estrogen and Related Receptor Antagonists / ICI 182,780

ICI 182,780

Catalog #: 1047
284 Citations Datasheet / COA / SDS
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1047/10
1047/50
1047/1
ICI 182,780 | CAS No. 129453-61-8 | Estrogen and Related Receptor Antagonists
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Description: Estrogen receptor antagonist
Alternative Names: Fulvestrant

Chemical Name: 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol

Purity: ≥99%

Product Details
Citations (284)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ICI 182,780 is a high affinity estrogen receptor antagonist (IC50 = 0.29 nM), devoid of any partial agonism both in vitro and in vivo. ICI 182,780 is a high affinity agonist at the membrane estrogen receptor GPER. ICI 182,780 inhibits MCF-7 human breast cancer cell growth in vitro and shows antitumor activity in mice models. ICI 182,780 penetrates the blood-brain-barrier and has neuronal functional effects in vivo.

Technical Data

M.Wt:
606.77
Formula:
C32H47F5O3S
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
129453-61-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Estrogen Regulates Hepcidin Expression via GPR30-BMP6-Dependent Signaling in Hepatocytes.
    Ikeda Y, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T
    PLoS ONE, 2012;7(7):e40465.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. Estradiol reduces ferrous citrate complex-induced NOS2 up-regulation in cerebral endothelial cells by interfering the nuclear factor kappa B transactivation through an estrogen receptor beta-mediated pathway.
    Chen L, Lee W
    PLoS ONE, 2013;8(12):e84320.
  4. Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir
    B Das, C Dobrowolsk, B Luttge, S Valadkhan, N Chomont, R Johnston, P Bacchetti, R Hoh, M Gandhi, SG Deeks, E Scully, J Karn
    Proc. Natl. Acad. Sci. U.S.A., 2018;115(33):E7795-E7804.
  5. Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.
    Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J, Pierce WM, Ivanova MM, Bates PJ, Appana SN, Datta S, Kulesza P, McBryan J, Young LS, Klinge CM
    PLoS ONE, 2012;7(5):e38278.
  6. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.
    Cook K, Shajahan A, Warri A, Jin L, Hilakivi-Clarke L, Clarke R
    Cancer Res, 2012;72(13):3337-49.
  7. PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
    Kastrati I, Canestrari E, Frasor J
    Oncogene, 2015;34(18):2309-16.
  8. ERbeta-mediated estradiol enhances epithelial mesenchymal transition of lung adenocarcinoma through increasing transcription of midkine.

    Mol. Endocrinol., 2012;26(8):1304-15.
  9. Epidermal growth factor receptor (EGFR) signaling is a key mediator of hormone-induced leukocyte infiltration in the pubertal female mammary gland.
    Aupperlee M, Zhao Y, Tan Y, Leipprandt J, Bennett J, Haslam S, Schwartz R
    Endocrinology, 2014;155(6):2301-13.
  10. Estrogen receptor (ER) agonists differentially regulate neuroangiogenesis in peritoneal endometriosis via the repellent factor SLIT3.
    Greaves E, Collins F, Esnal-Zufiaurre A, Giakoumelou S, Horne A, Saunders P
    Endocrinology, 2014;155(10):4015-26.
  11. Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor alpha.
    Valera M, Gratacap M, Gourdy P, Lenfant F, Cabou C, Toutain C, Marcellin M, Saint Laurent N, Sie P, Sixou M, Arnal J, Payrastre B
    Blood, 2012;120(8):1703-12.
  12. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.
    Privette Vinnedge L, Ho S, Wikenheiser-Brokamp K, Wells S
    PLoS ONE, 2012;7(10):e46985.
  13. The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.
    Kirkegaard T, Yde C, Kveiborg M, Lykkesfeldt A
    Int J Oncol, 2014;45(1):393-400.
  14. D538G mutation in estrogen receptor-alpha: A novel mechanism for acquired endocrine resistance in breast cancer.
    Merenbakh-Lamin K, Ben-Baruch N, Yeheskel A, Dvir A, Soussan-Gutman L, Jeselsohn R, Yelensky R, Brown M, Miller V, Sarid D, Rizel S, Klein B, Rubinek T, Wolf I
    Cancer Res, 2013;73(23):6856-64.
  15. Inhibition of ERbeta induces resistance to cisplatin by enhancing Rad51-mediated DNA repair in human medulloblastoma cell lines.
    Wilk A, Waligorska A, Waligorski P, Ochoa A, Reiss K
    PLoS ONE, 2012;7(3):e33867.
  16. Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts.
    Richardson TE, Yu AE, Wen Y, Yang SH, Simpkins JW
    PLoS ONE, 2012;7(4):e34600.
  17. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.
    Thomas et al.
    Endocrinology, 2005;146:624
  18. Comparison between novel steroid-like and conventional nonsteroidal antioestrogens in inhibiting OE and IGF-I induced proliferation of human breast cancer-derived cells.
    de Cupis et al.
    Br.J.Pharmacol., 1995;116:2391
  19. ICI 182,780 (FaslodexTM): Development of a novel, "pure" antiestrogen.
    Howell et al.
    Cancer, 2000;89:817
  20. A potent specific pure antiestrogen with clinical potential.
    Wakeling et al.
    Cancer Res., 1991;51:3867

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Citations for ICI 182,780

The citations listed below are publications that use Tocris products. Selected citations for ICI 182,780 include:

284 Citations: Showing 1 - 10

  1. Pancreatic Ins content regulation by the estrogen receptor ER alpha.
    Authors: Alonso-Magdalena Et al.
    PLoS One  ;3:e2069
  2. Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer.
    Authors: Demas Et al.
    Front Oncol  2019;9:686
  3. Chronic cadmium exposure decreases the dependency of MCF7 breast cancer cells on ERα.
    Authors: Bloomfield and Louie
    Sci Rep  2019;9:12135
  4. TAX mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.
    Authors: Cortes Et al.
    Oncogene  2019;38:2910
  5. Data on UPLC/MS method validation for the biodegradation of pharmaceuticals and intermediates by a fungal consortium and on T47DK-Bluc reporter gene assay to assess the reduction of their estrogenic activity.
    Authors: Kasonga Et al.
    Data Brief  2019;25:104336
  6. GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.
    Authors: Cortes Et al.
    EMBO Rep  2019;20
  7. TAX mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival.
    Authors: Cortes Et al.
    EMBO Rep  2019;20
  8. F-Spondin Is the Signal by Which 2-Methoxyestradiol Induces Apoptosis in the Endometrial Cancer Cell Line Ishikawa.
    Authors: Rincó n-Rodriguez Et al.
    Int J Mol Sci  2019;20
  9. Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer.
    Authors: Hosford Et al.
    Mol Oncol  2019;13:1778
  10. Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance.
    Authors: Kaymak Et al.
    Oncotarget  2018;9:28666
  11. Brain Aromatase Modulates Serotonergic Neuron by Regulating Serotonin Levels in Zebrafish Embryos and Larvae.
    Authors: Ulhaq and Kishida
    Front Endocrinol (Lausanne)  2018;9:230
  12. A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780.
    Authors: Rabaglino Et al.
    Physiol Rep  2018;6:e13871
  13. 17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes.
    Authors: Jallow Et al.
    J Endocr Soc  2018;2:293
  14. The impact of 27-hydroxycholesterol on endometrial cancer proliferation.
    Authors: Gibson Et al.
    Endocr Relat Cancer  2018;25:381
  15. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer.
    Authors: Du Et al.
    Breast Cancer Res  2018;20:106
  16. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells.
    Authors: Li Et al.
    Endocrinology  2018;159:285
  17. Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors.
    Authors: Simões Et al.
    Ther Adv Med Oncol  2018;10:1758835918766180
  18. Estrogen enhances mismatch repair by induction of MLH1 expression via estrogen receptor-β.
    Authors: Lu Et al.
    Oncotarget  2017;8:38767
  19. Structural and molecular mechanisms of cytokine-mediated endocrine resistance in human breast cancer cells.
    Authors: Stender
    Mol Cell  2017;65(6):1122
  20. E2 via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells.
    Authors: Panza Et al.
    Tumour Biol  2017;39:1010428317701640
  21. Role of inducible nitric oxide synthase in endothelium-independent relaxation to RLX in rat aorta.
    Authors: Wong Et al.
    Br J Pharmacol  2017;174:718
  22. OE Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1.
    Authors: Lou Et al.
    Int J Biol Sci  2017;13:434
  23. Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors.
    Authors: Zhu
    PLoS One  2017;12(2):e0171390
  24. Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells.
    Authors: Pastore Et al.
    Biol Reprod  2016;94:139
  25. Multiple direct and indirect mechanisms drive estrogen-induced tumor growth in high grade serous ovarian cancers.
    Authors: Ciucci Et al.
    Oncotarget  2016;7:8155
  26. Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus.
    Authors: Maselli Et al.
    Front Vet Sci  2016;7:3
  27. Antiestrogen resistant cell lines expressing estrogen receptor α mutations upregulate the unfolded protein response and are killed by BHPI
    Authors: Mao Et al.
    Scientific Reports  2016;6:34753
  28. Estrogen protects against DA neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway.
    Authors: Bains and Roberts
    Neurosci Lett  2016;610:79
  29. NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer.
    Authors: Gupta Et al.
    Oncogene  2016;35:5860
  30. Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors.
    Authors: Peretz Et al.
    Am J Physiol Lung Cell Mol Physiol  2016;310:L415
  31. Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes.
    Authors: Diep Et al.
    Steroids  2016;114:48
  32. Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  33. Differential effects of estrogen and estrogen receptor antagonist, ICI 182 780, on the expression of calbindin-D9k in rat pituitary prolactinoma GH3 cells.
    Authors: Wang Et al.
    Cancer Cell Int  2015;7:8498
  34. A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation.
    Authors: Tomita Et al.
    Nat Commun  2015;6:6966
  35. A short report: PAMM, a novel antioxidant protein, induced by oxidative stress.
    Authors: Xu Et al.
    Redox Biol  2015;6:446
  36. Altered radiation responses of breast cancer cells resistant to hormonal therapy.
    Authors: Luzhna Et al.
    Mol Cell Biol  2015;6:1678
  37. Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro.
    Authors: Harvey Et al.
    Reprod Toxicol  2015;51:72
  38. Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulves. action and breast cancer prognosis.
    Authors: Miyoshi Et al.
    Biol Sex Differ  2015;4:e172
  39. Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: OE regulation.
    Authors: Castro Et al.
    Biol Res  2015;48:56
  40. New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulves. treatment and cross-resistance between letr. and exeme.
    Authors: Hole Et al.
    BMC Cancer  2015;46:1481
  41. NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer.
    Authors: Hu Et al.
    Oncogenesis  2015;35:379
  42. PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
    Authors: Kastrati Et al.
    Oncogene  2015;34:2309
  43. The Effects of Steroid Implant and Dietary Soybean Hulls on Estrogenic Activity of Sera of Steers Grazing Toxic Endophyte-Infected Tall Fescue Pasture.
    Authors: Shappell Et al.
    Cancer Lett  2015;2:30
  44. Estrogenic and anti-estrogenic activity of off-the-shelf hair and skin care products.
    Authors: Myers Et al.
    BMC Cancer  2015;25:271
  45. Effects of estrogen on growth and smooth muscle differentiation of vascular wall-resident CD34(+) stem/progenitor cells.
    Authors: Wu Et al.
    Atherosclerosis  2015;240:453
  46. Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader.
    Authors: Wardell Et al.
    Endocr Relat Cancer  2015;22:713
  47. Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamox. resistant breast cancer.
    Authors: Larsen Et al.
    Aging Cell  2015;15:239
  48. Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study.
    Authors: Segovia-Mendoza Et al.
    J Biol Chem  2015;15:21
  49. Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway.
    Authors: Xiong Et al.
    Breast Cancer Res Treat  2015;14:867
  50. Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling.
    Authors: Zhou Et al.
    Endocrinology  2015;14:540
  51. The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.
    Authors: Bean Et al.
    Oncotarget  2015;149:69
  52. Estrogen promotes luteolysis by redistributing prostaglandin F2α receptors within primate luteal cells.
    Authors: Kim Et al.
    Reproduction  2015;149:453
  53. Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
    Authors: Simões Et al.
    Cell Cycle  2015;12:1968
  54. Effects of Atrazine on Estrogen Receptor α- and G Protein-Coupled Receptor 30-Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts.
    Authors: Albanito Et al.
    Environ Health Perspect  2015;123:493
  55. Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.
    Authors: Gottardo Et al.
    PLoS One  2014;9:e111548
  56. Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs.
    Authors: Seo Et al.
    Breast Cancer Res  2014;90:99
  57. Diaryl and heteroaryl sulfides: synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents.
    Authors: Yonova Et al.
    J Org Chem  2014;79:1947
  58. Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton.
    Authors: Giretti Et al.
    Front Endocrinol (Lausanne)  2014;5:80
  59. Functional analysis of MKP-1 and MKP-2 in breast cancer tamox. sensitivity.
    Authors: Haagenson Et al.
    Oncotarget  2014;5:1101
  60. Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells.
    Authors: Fan Et al.
    Eur J Cancer  2014;50:457
  61. A molecular model for the mechanism of acquired tamox. resistance in breast cancer.
    Authors: Fan Et al.
    Eur J Cancer  2014;50:2866
  62. Anti-tumor efficacy of fulves. in estrogen receptor positive gastric cancer.
    Authors: Yi Et al.
    Sci Rep  2014;4:7592
  63. β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression.
    Authors: Jafaar Et al.
    Int J Oncol  2014;44:1365
  64. Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries.
    Authors: Hill and Muldrew
    Clin Exp Pharmacol Physiol  2014;41:430
  65. Egr1 protein acts downstream of estrogen-leukemia inhibitory factor (LIF)-STAT3 pathway and plays a role during implantation through targeting Wnt4.
    Authors: Liang Et al.
    J Biol Chem  2014;289:23534
  66. Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates α2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat.
    Authors: Nag and Mokha
    Am J Physiol Regul Integr Comp Physiol  2014;267:122
  67. Suppression of autophagic activation in the mouse uterus by estrogen and progesterone.
    Authors: Choi Et al.
    Cell Rep  2014;221:39
  68. Hormonal regulation of epithelial organization in a three-dimensional breast tissue culture model.
    Authors: Speroni Et al.
    PLoS One  2014;20:42
  69. In vitro chronic administration of ERbeta selective ligands and prostate cancer cell growth: hypotheses on the selective role of 3beta-adiol in AR-positive RV1 cells.
    Authors: Colciago Et al.
    Biomed Res Int  2014;2014:801473
  70. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.
    Authors: Alao Et al.
    BMC Cancer  2014;14:853
  71. Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover.
    Authors: Adomas Et al.
    BMC Cancer  2014;14:278
  72. OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism.
    Authors: Oróstica Et al.
    Reproduction  2014;148:285
  73. Estrogen receptor-α signaling and localization regulates autophagy and unfolded protein response activation in ER+ breast cancer.
    Authors: Cook and Clarke
    Steroids  2014;1
  74. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.
    Authors: Morandi Et al.
    Cancer Res  2013;73:3783
  75. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression.
    Authors: Giordano Et al.
    Free Radic Biol Med  2013;58:98
  76. Expression of the aryl hydrocarbon receptor is not required for the proliferation, migration, invasion, or estrogen-dependent tumorigenesis of MCF-7 breast cancer cells.
    Authors: Spink Et al.
    Mol Carcinog  2013;52:544
  77. Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
    Authors: Johansson Et al.
    Nat Commun  2013;4:2175
  78. Induction of hepatic multidrug resistance-associated protein 3 by ethynylOE is independent of cholestasis and mediated by estrogen receptor.
    Authors: Ruiz Et al.
    Proc Natl Acad Sci U S A  2013;41:275
  79. The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-OE.
    Authors: Smith Et al.
    Am J Physiol Endocrinol Metab  2013;305:E632
  80. ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1.
    Authors: Greaves Et al.
    Hum Reprod  2013;28:2490
  81. The effect of estrogen compounds on human embryoid bodies.
    Authors: Kim Et al.
    Proc Natl Acad Sci U S A  2013;20:661
  82. OOE signalling through the Akt-mTORC1-S6K1.
    Authors: Varea Et al.
    Biochim Biophys Acta  2013;1833:1052
  83. Amphiregulin mediates progesterone-induced mammary ductal development during puberty.
    Authors: Aupperlee Et al.
    J Neurosci  2013;15:R44
  84. OE promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis.
    Authors: Aida-Yasuoka Et al.
    J Neurosci  2013;15:R10
  85. Fulvestrant regulates epidermal growth factor (EGF) family ligands to activate EGF receptor (EGFR) signaling in breast cancer cells.
    Authors: Zhang Et al.
    Environ Health Perspect  2013;139:351
  86. Differential action of monohydroxylated polycyclic aromatic hydrocarbons with estrogen receptors α and β.
    Authors: Sievers Et al.
    Proc Natl Acad Sci U S A  2013;132:359
  87. Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.
    Authors: Teng Et al.
    Toxicol Sci  2013;131:71
  88. 17β-OE-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes.
    Authors: Mahmoodzadeh Et al.
    Cardiovasc Res  2012;96:411
  89. Modulation of ovine SBD-1 expression by 17beta-OE in ovine oviduct epithelial cells.
    Authors: Wen Et al.
    BMC Vet Res  2012;8:143
  90. Bisphenol A inhibits follicle growth and induces atresia in cultured mouse antral follicles independently of the genomic estrogenic pathway.
    Authors: Peretz Et al.
    Biol Reprod  2012;87:63
  91. p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF.
    Authors: Leal Et al.
    PLoS One  2012;7:e49817
  92. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.
    Authors: Vinnedge Et al.
    Neuroscience  2012;7:e46985
  93. Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos.
    Authors: Brion Et al.
    PLoS One  2012;7:e36069
  94. Insotropic effect of the non-steroidal compound STX in pancreatic β-cells.
    Authors: Ropero Et al.
    PLoS One  2012;7:e34650
  95. Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts.
    Authors: Richardson Et al.
    Endocrinology  2012;7:e34600
  96. Estrogen receptor β dependent attenuation of cytokine-induced cyclooxygenase-2 by androgens in human brain vascular smooth muscle cells and rat mesenteric arteries.
    Authors: Zuloaga Et al.
    Exp Neurol  2012;77:835
  97. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.
    Authors: Cook Et al.
    Int J Mol Sci  2012;72:3337
  98. Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes.
    Authors: Rodriguez-Ubreva Et al.
    Nucleic Acids Res  2012;40:1954
  99. Estrogen receptor is activated by korean red ginseng in vitro but not in vivo.
    Authors: Shim and Lee
    J Ginseng Res  2012;36:169
  100. Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: role of endothelial nitric oxide synthase and estrogen receptor-β.
    Authors: Zhang Et al.
    J Cell Physiol  2012;227:146
  101. Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia.
    Authors: Park Et al.
    Proc Natl Acad Sci U S A  2012;20:183
  102. MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy.
    Authors: Bobustuc Et al.
    Mol Med  2012;18:913
  103. OE increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators.
    Authors: González-Arenas Et al.
    Biochim Biophys Acta  2012;1823:379
  104. Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.
    Authors: Niu Et al.
    J Cereb Blood Flow Metab  2012;153:2283
  105. OE directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons.
    Authors: Wang and Kuehl-Kovarik
    Brain Res  2012;1436:81
  106. Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice.
    Authors: Babu Et al.
    J Nutr  2012;142:724
  107. Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat.
    Authors: Cao Et al.
    J Pain  2012;13:685
  108. Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation.
    Authors: Antoon Et al.
    Cancer Biol Ther  2012;13:1026
  109. Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha.
    Authors: Collins-Burow Et al.
    J Steroid Biochem Mol Biol  2012;132:186
  110. Estrogen-like activity of aqueous extract from Agrimonia pilosa Ledeb. in MCF-7 cells.
    Authors: Lee Et al.
    Endocrinology  2012;12:260
  111. Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis.
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    Clin Sci (Lond)  2012;123:509
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