ICI 204,448 hydrochloride
Chemical Name: (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride
Purity: ≥98%
Biological Activity
ICI 204,448 hydrochloride is a peripherally acting κ agonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Antinociceptive effect of a κ-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy.
Ke?ta et al.
Eur.J.Pharmacol., 1995;277:275 -
ICI-204,448: a κ-opioid agonist with limited access to the CNS.
Shaw et al.
Br.J.Pharmacol., 1989;96:986
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Citation for ICI 204,448 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ICI 204,448 hydrochloride include:
1 Citation: Showing 1 - 1
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The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects.
Authors: Butelman Et al.
Psychopharmacology (Berl) 2010;210:253
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