Idebenone
Discontinued Product
Chemical Name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
Purity: ≥99%
Biological Activity
Idebenone is an antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo. Inhibits apoptosis of astrocytes via increased NGF production.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review.
Zs-Nagy
Arch.Gerontol.Geriatr., 1990;11:177 -
Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes.
Civenni et al.
Eur.J.Pharmacol., 1999;370:161 -
CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production.
Takuma et al.
Eur.J.Pharmacol., 2000;406:333
Product Datasheets
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Citation for Idebenone
The citations listed below are publications that use Tocris products. Selected citations for Idebenone include:
1 Citation: Showing 1 - 1
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Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress.
Authors: Liu Et al.
Antioxid Redox Signal 2014;21:1571
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