Home / IL-17/IL-17A / IL-17/IL-17A [Unconjugated]

IL-17/IL-17A [Unconjugated]

Catalog #: LUM421
6 Citations Datasheet / COA / SDS
Newer Version Available: LXSAMSM
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Discontinued Product

LUM421 has been discontinued and is replaced by LXSAMSM.

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Citations (6)
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Summary Background Product Datasheets Related Research Areas

IL-17/IL-17A [Unconjugated] Summary

Product Datasheets

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COA
SDS

Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: IL-17/IL-17A

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Long Name
Interleukin 17
Entrez Gene IDs
3605 (Human); 16171 (Mouse); 301289 (Rat); 449530 (Porcine); 481837 (Canine); 102119976 (Cynomolgus Monkey)
Alternate Names
CTLA8; CTLA-8; IL17; IL-17; IL17A; IL-17A

Citations for IL-17/IL-17A [Unconjugated]

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.
    Authors: Arias, Mauricio, Van Roey, Griet A, Tregoning, John S, Moutaftsi, Magdalin, Coler, Rhea N, Windish, Hillarie, Reed, Steven G, Carter, Darrick, Shattock, Robin J
    PLoS ONE, 2012-07-19;7(7):e41144.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  2. Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease.
    Authors: Chantrathammachart P, Mackman N, Sparkenbaugh E
    Blood, 2012-06-01;120(3):636-46.
    Species: Mouse
    Sample Types: Plasma
  3. Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury.
    Authors: Gill SE, Huizar I, Bench EM
    Am. J. Pathol., 2009-12-11;176(1):64-73.
    Species: Mouse
    Sample Types: BALF
  4. Effects of age on the synergistic interactions between lipopolysaccharide and mechanical ventilation in mice.
    Authors: Smith LS, Gharib SA, Frevert CW, Martin TR
    Am. J. Respir. Cell Mol. Biol., 2009-11-09;43(4):475-86.
    Species: Mouse
    Sample Types: Tissue Homogenates
  5. Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia.
    Authors: Ventura CL, Higdon R, Hohmann L, Martin D, Kolker E, Liggitt HD, Skerrett SJ, Rubens CE
    Infect. Immun., 2008-10-13;76(12):5862-72.
    Species: Mouse
    Sample Types: BALF
  6. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice.
    Authors: Tan SL, Zhao J, Bi C, Chen XC, Hepburn DL, Wang J, Sedgwick JD, Chintalacharuvu SR, Na S
    J. Immunol., 2006-03-01;176(5):2872-9.
    Species: Mouse
    Sample Types: Cell Culture Supernates

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