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IRAK3 Degrader 23

Catalog #: 7983 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7983/5
IRAK3 Degrader 23 | CAS No. 2712600-00-3 | Active Degraders
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Description: IRAK3 Degrader (PROTAC®

Chemical Name: 2-(2,6-Dioxo-3-piperidyl)-5-[4-[2-[1-[4-[4-[cis-4-[(5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]-piperazin-1-yl]-4-oxo-butanoyl]-4-piperidyl]ethyl]piperazin-1-yl]-isoindoline-1,3-dione

Purity: ≥98%

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Biological Activity

IRAK3 Degrader 23 is a potent and selective IRAK3 Degrader (PROTAC®; DC50 = 2 nM; Dmax = 98% in THP1 cells and primary macrophages), requires CRBN and IRAK3 binding for Degrader activity. Also inhibits CDK11, CDK8, TRKC and GSG2 (IC50 values are 16 nM, 36 nM, 100 nM and 110 nM respectively).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
878.09
Formula:
C47H63N11O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2712600-00-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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