IRL-1620
Discontinued Product
Purity: ≥95%
Biological Activity
IRL-1620 is a potent and highly selective ETB endothelin receptor agonist (Ki values are 0.016 and 1900 nM at ETB and ETA receptors respectively). Discriminates two subpopulations of ETB receptors. IRL-1620 prevents oxidative stress and cognitive impairment induced by Aβ in normal and diabetic rats; in a rat brain ischemia model it is neuroprotective, increases angiogenesis and neurogenesis, and promotes the recovery of neuronal function. Also promotes neural progenitor cell differentiation and maturation in vivo and in vitro.Technical Data
(Modifications: Asp-1 = Suc-Asp)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart.
Choisy SC, Cheng H, Smith GL, James AF, Hancox JC
PLoS ONE, 2012;7(3):e33448. -
Endothelin; progress in pharmacology and physiology.
Haynes et al.
TiPS, 1993;14:225 -
Suc-[Glu9, Ala11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ETB receptors in guinea-pig bronchus.
Mazzoni et al.
Br.J.Pharmacol., 1999;127:1406 -
A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor.
Takai et al.
Biochem.Biophys.Res.Commun., 1992;184:953 -
Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.
Sakamoto et al.
J.Biol.Chem., 1993;268:8547
Product Datasheets
Citations for IRL-1620
The citations listed below are publications that use Tocris products. Selected citations for IRL-1620 include:
8 Citations: Showing 1 - 8
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Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B.
Authors: Durgan Et al.
J Cereb Blood Flow Metab 2015;35:402
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Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats.
Authors: Ou Et al.
J Cell Physiol 2014;229:489
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Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca2+]i in mesenteric microvessels of pregnant rats.
Authors: Mazzuca Et al.
Br J Pharmacol 2013;169:1335
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Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart.
Authors: Choisy Et al.
PLoS One 2012;7:e33448
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Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
Authors: Hamby Et al.
Purinergic Signal 2012;32:14489
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Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway.
Authors: Giachini Et al.
Am J Physiol Heart Circ Physiol 2009;296:H489
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Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
Authors: McQueen Et al.
Br J Pharmacol 2007;151:278
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Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
Authors: Khan Et al.
Br J Pharmacol 2006;147:607
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