IRL-2500
Discontinued Product
Chemical Name: N-3-[1,1'-Biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-L-tryptophan
Purity: ≥99%
Biological Activity
IRL-2500 is a potent endothelin receptor antagonist; shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.
Balwierczak et al.
J.Cardiovasc.Pharmacol., 1995;26:S393 -
Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role of endothelin ETB receptors.
Leung et al.
J.Cardiovasc.Pharmacol., 2002;39:533 -
Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously hypertensive and Wistar-Kyoto rats.
Webb et al.
J.Cardiovasc.Pharmacol., 1995;26:S389
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Citation for IRL-2500
The citations listed below are publications that use Tocris products. Selected citations for IRL-2500 include:
1 Citation: Showing 1 - 1
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Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca2+ in adult cardiac myocytes.
Authors: Merlen Et al.
J Mol Cell Cardiol 2013;62:189
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