Ischemin sodium salt
Chemical Name: 5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium salt
Purity: ≥99%
Biological Activity
Ischemin sodium salt is a CBP bromodomain inhibitor. Inhibits p53 interaction with CBP and decreases p53 transcriptional activity. Protects against Doxorubicin-induced apoptosis in cardiomyocytes in vitro. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.
Borah et al.
Chem.Biol., 2011;18:531
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