ISOX DUAL

Name: ISOX DUAL
Brand: Tocris Bioscience
SKU: 5806

Catalog #: 5806 Datasheet / COA / SDS

Discontinued Product

5806 has been discontinued.

View all Bromodomain Inhibitors products.

ISOX DUAL | CAS No. 1962928-22-8 | Bromodomain Inhibitors

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Description: Dual BRD4 and CBP/p300 bromodomain inhibitor

Chemical Name: [3-[4-[2-[5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazol-2-yl]ethyl]phenoxy]propyl]dimethylamine

Purity: ≥98%

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Product Details

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

ISOX DUAL is a dual CBP/p300 and BRD4 bromodomain inhibitor (IC₅₀ values are 0.65 and 1.5 μM for CBP and BRD4 respectively). Downregulates IL-6, IL-1β and IFN-β in macrophages.

Technical Data

M.Wt:

531.69

Formula:

C₃₁H₄₁N₅O₃

Solubility:

Soluble to 100 mM in 1eq. HCl and to 50 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1962928-22-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from Pfizer Inc.

Background References

Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities.
Chekler et al.
Chem.Biol., 2015;22:1588

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