Ivabradine hydrochloride
Chemical Name: 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
Purity: ≥98%
Biological Activity
Ivabradine hydrochloride is a HCN channel blocker (IC50 is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits If pacemaker current in sinoatrial node cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49.
Thollon et al.
Br.J.Pharmacol., 1994;112:37 -
HCN channel modulators: the need for selectivity.
Novella Romanelli et al.
Curr.Top.Med.Chem., 2016;16:1764
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Citation for Ivabradine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Ivabradine hydrochloride include:
1 Citation: Showing 1 - 1
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BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons.
Authors: Joseph J Et al.
J Neurophysiol 2020;123:2449-2464
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