JMV 449
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Description: Potent neurotensin receptor agonist
Purity: ≥95%
Biological Activity
JMV 449 is a potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.Technical Data
M.Wt:
746.96
Formula:
C38H66N8O7
Sequence:
KKPYIL
(Modifications: Lys-1 - Lys-2 peptide bond replaced with Ψ(CH2-NH))
Solubility:
Soluble to 0.80 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
139026-66-7
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.
Saada S, Marget P, Fauchais A, Lise M, Chemin G, Sindou P, Martel C, Delpy L, Vidal E, Jaccard A, Troutaud D, Lalloue F, Jauberteau M
J Immunol, 2012;189(11):5293-303. -
Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability.
Lugrin et al.
Eur.J.Pharmacol., 1991;205:191 -
JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse.
Dubuc et al.
Eur.J.Pharmacol., 1992;219:327 -
Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia.
Torup et al.
Neurosci.Lett., 2003;351:173
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