JNJ 0966
Chemical Name: N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide
Purity: ≥98%
Biological Activity
JNJ 0966 is a pro-MMP9 activation inhibitor (IC50 = 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion in in vitro assays. Reduces motor impairment in a mouse EAE model. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.
Scannevin et al.
J.Biol.Chem., 2017;292:17963
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