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JNJ 303

Catalog #: 3899
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3899/10
3899/50
JNJ 303 | CAS No. 878489-28-2 | Voltage-gated Potassium Channel Blockers
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Description: Potent and selective IKs blocker

Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

JNJ 303 is a potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).

Technical Data

M.Wt:
440.98
Formula:
C21H29ClN2O4S
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
878489-28-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Janssen Pharmaceutica NV

Background References

  1. Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening?
    Towart et al.
    J.Pharm.Toxicol.Meth, 2009;60:1

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Citations for JNJ 303

The citations listed below are publications that use Tocris products. Selected citations for JNJ 303 include:

2 Citations: Showing 1 - 2

  1. Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation.
    Authors: Jens Et al.
    Elife  2020;9
  2. Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes.
    Authors: Bj?rk Et al.
    Front Physiol  2017;8:884

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