Home / Histamine H4 Receptor Antagonists / JNJ 39758979 dihydrochloride

JNJ 39758979 dihydrochloride

Catalog #: 6279 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6279/25
6279/5
JNJ 39758979 dihydrochloride | Histamine H4 Receptor Antagonists
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Description: High affinity and selective histamine H4 antagonist; orally bioavailable

Chemical Name: 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride

Purity: ≥98%

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Biological Activity

JNJ 39758979 dihydrochloride is a high affinity and selective histamine H4 antagonist (Ki = 12.5 nM). Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.

Technical Data

M.Wt:
294.22
Formula:
C11H19N5.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Janssen Pharmaceutica N.V.

Background References

  1. Clinical and preclinical characterization of the histamine H4 receptor antagonist JNJ-39758979.
    Thurmond et al.
    J.Pharmacol.Exp.Ther., 2014;349:176

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