Home / Histamine H4 Receptor Antagonists / JNJ 7777120

JNJ 7777120

Catalog #: 4021
2 Citations Datasheet / COA / SDS
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4021/5
4021/25
JNJ 7777120 | CAS No. 459168-41-3 | Histamine H4 Receptor Antagonists
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Description: Selective H4 antagonist

Chemical Name: 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

JNJ 7777120 is a histamine H4 receptor antagonist; displays high affinity (Ki = 4.5 nM) and is >1000-fold selective for H4 over other histamine receptors.

Technical Data

M.Wt:
277.75
Formula:
C14H16ClN3O
Solubility:
Soluble to 100 mM in 1eq. HCl and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
459168-41-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

Background References

  1. Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor.
    Glatzer F, Gschwandtner M, Ehling S, Rossbach K, Janik K, Klos A, Baumer W, Kietzmann M, Werfel T, Gutzmer R
    J Allergy Clin Immunol, 2013;132(6):1358-67.
  2. In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties.
    Strakhova et al.
    Br.J.Pharmacol., 2009;157:44
  3. The first potent and selective non-imidazole human histamine H4 receptor antagonists.
    Jablanowski et al.
    J.Med.Chem., 2003;46:3957
  4. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.
    Thurmond et al.
    J.Pharmacol.Exp.Ther., 2004;309:404

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Citations for JNJ 7777120

The citations listed below are publications that use Tocris products. Selected citations for JNJ 7777120 include:

2 Citations: Showing 1 - 2

  1. Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth.
    Authors: David Et al.
    Elife  2020;9
  2. Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch.
    Authors: Fang Et al.
    Immunity  2019;50:1163-1171.e5

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