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JQ dS-4

Catalog #: 8152 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8152/2
JQ dS-4 | CAS No. 2688882-69-9 | Active Degraders
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Description: BRG1/SMARCA4 Degrader (PROTAC®)

Chemical Name: 3-((4-(3-(2-Chloropyridin-4-yl)ureido)pyridin-2-yl)ethynyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)benzamide

Purity: ≥95%

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Biological Activity

JQ dS-4 is a Brahma-related gene 1 (BRG1)/BRM/SMARCA4 Degrader (PROTAC®; IC50 range = 9 - 390 nM in glioma models and cell lines). Comprises a BRG1 inhibitor joined by a linker to a cereblon (CRBN) E3 ligase ligand. Completely degrades BRG1 after 48 and 72 hours in HSJD-DIPG007 and SU-DIPGXIIIP cells and reduces viability of a variety of cancer cell lines including H3K27M glioma, prostate, thyroid and salivary gland.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
719.16
Formula:
C37H31ClN8O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2688882-69-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Product Datasheets

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